Pharmacokinetics and safety of intravenous cidofovir for life-threatening viral infections in pediatric hematopoietic stem cell transplant recipients

Antimicrobial Agents and Chemotherapy
Amy E Caruso BrownMyron J Levin

Abstract

Children undergoing hematopoietic stem cell transplantation (HSCT) are at risk for life-threatening viral infections. Cidofovir is often used as a first-line agent for adenovirus infections, despite the absence of randomized controlled trials with HSCT patients, and as a second-line agent for resistant herpesvirus infections. The frequency and severity of adverse effects, particularly nephrotoxicity, in pediatric HSCT recipients are unclear, and pharmacokinetics (PK) of cidofovir in children have not previously been reported. This study was an open-label, nonrandomized, single-dose pilot study to determine the safety and PK of cidofovir in pediatric HSCT recipients with symptomatic adenovirus, nucleoside-resistant cytomegalovirus (CMV) or herpes simplex virus (HSV), and/or human papovavirus infections. Subsequent dosing and frequency were determined by clinical response and side effects, as assessed by the treating physician. Blood and urine samples were obtained from patients for PK studies and assessment of toxicity and virologic response. Twelve patients were enrolled (median age, 9 years; 33.5 days posttransplantation). Four of seven patients with adenovirus infection were successfully treated and eventually cleared their i...Continue Reading

References

Jun 1, 1995·Antimicrobial Agents and Chemotherapy·K C CundyH S Jaffe
Oct 22, 1998·Advances in Experimental Medicine and Biology·C Cobelli, D M Foster
Nov 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William J MullerRoger Giller
Mar 31, 2007·Kidney International·A Akcan-ArikanS L Goldstein
Oct 16, 2008·Clinical Microbiology Reviews·Marcela Echavarría
Apr 28, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·V A BhadriP J Shaw
Aug 3, 2010·Journal of Pharmaceutical and Biomedical Analysis·Jeremiah D MomperRaman Venkataramanan
Sep 15, 2010·Blood·Caroline A LindemansJaap Jan Boelens
Oct 4, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Diana F FlorescuCharles van der Horst
Sep 25, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Minna KoskenvuoHans H Hirsch
Nov 14, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S Matthes-MartinUNKNOWN Fourth European Conference on Infections in Leukemia
Sep 14, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·H J KwonB Cho
Sep 27, 2013·The New England Journal of Medicine·Francisco M MartyUNKNOWN CMX001-201 Clinical Study Group

❮ Previous
Next ❯

Citations

Apr 5, 2016·Expert Review of Hematology·Enrico MaffiniBenedetto Bruno
Nov 1, 2016·Expert Review of Hematology·Franco LocatelliPietro Merli
Jun 17, 2020·Journal of Clinical Pharmacology·Amer Al-KhoujaGilbert J Burckart
Apr 19, 2017·Journal of the Pediatric Infectious Diseases Society·Surabhi B VoraJanet A Englund
Nov 20, 2016·Folia Microbiologica·Daniele Zendrini RechenchoskiCarlos Nozawa
Nov 12, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Sanya J ThomasDebra J Lugo
Aug 28, 2020·Microorganisms·Bratati Saha, Robin J Parks
Sep 14, 2021·Clinical Transplantation·Aditya ChandorkarJose F Camargo

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Gertjan LugthartArjan C Lankester
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
William J MullerRoger Giller
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Parinda A MehtaStella M Davies
© 2022 Meta ULC. All rights reserved