Abstract
Children undergoing hematopoietic stem cell transplantation (HSCT) are at risk for life-threatening viral infections. Cidofovir is often used as a first-line agent for adenovirus infections, despite the absence of randomized controlled trials with HSCT patients, and as a second-line agent for resistant herpesvirus infections. The frequency and severity of adverse effects, particularly nephrotoxicity, in pediatric HSCT recipients are unclear, and pharmacokinetics (PK) of cidofovir in children have not previously been reported. This study was an open-label, nonrandomized, single-dose pilot study to determine the safety and PK of cidofovir in pediatric HSCT recipients with symptomatic adenovirus, nucleoside-resistant cytomegalovirus (CMV) or herpes simplex virus (HSV), and/or human papovavirus infections. Subsequent dosing and frequency were determined by clinical response and side effects, as assessed by the treating physician. Blood and urine samples were obtained from patients for PK studies and assessment of toxicity and virologic response. Twelve patients were enrolled (median age, 9 years; 33.5 days posttransplantation). Four of seven patients with adenovirus infection were successfully treated and eventually cleared their i...Continue Reading
References
Jun 1, 1995·Antimicrobial Agents and Chemotherapy·K C CundyH S Jaffe
Mar 1, 1996·Antiviral Research·M WachsmanP S Lietman
Oct 22, 1998·Advances in Experimental Medicine and Biology·C Cobelli, D M Foster
Mar 27, 1999·Clinical Pharmacokinetics·K C Cundy
Jan 12, 2001·Blood·P LjungmanC Cordonnier
Aug 16, 2002·Bone Marrow Transplantation·J A Zaia
Nov 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William J MullerRoger Giller
May 30, 2006·Transplantation·Usman YusufRandall T Hayden
Jun 29, 2006·British Journal of Haematology·Tobias FeuchtingerPeter Lang
Mar 31, 2007·Kidney International·A Akcan-ArikanS L Goldstein
Mar 1, 2008·Pediatric Transplantation·Evan J AndersonBen Z Katz
Oct 16, 2008·Clinical Microbiology Reviews·Marcela Echavarría
Apr 28, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·V A BhadriP J Shaw
Aug 25, 2009·Blood·Ann M LeenCatherine M Bollard
Aug 3, 2010·Journal of Pharmaceutical and Biomedical Analysis·Jeremiah D MomperRaman Venkataramanan
Sep 15, 2010·Blood·Caroline A LindemansJaap Jan Boelens
Oct 4, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Diana F FlorescuCharles van der Horst
Apr 14, 2012·Molecular Diagnosis & Therapy·Sabine BreuerThomas Lion
Sep 25, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Minna KoskenvuoHans H Hirsch
Nov 14, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S Matthes-MartinUNKNOWN Fourth European Conference on Infections in Leukemia
Dec 12, 2012·Bone Marrow Transplantation·S CesaroS Santarone
Sep 14, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·H J KwonB Cho
Sep 27, 2013·The New England Journal of Medicine·Francisco M MartyUNKNOWN CMX001-201 Clinical Study Group
Citations
Apr 5, 2016·Expert Review of Hematology·Enrico MaffiniBenedetto Bruno
Oct 18, 2016·Medicine·Yu Mi SeoJin Han Kang
Nov 1, 2016·Expert Review of Hematology·Franco LocatelliPietro Merli
Jun 17, 2020·Journal of Clinical Pharmacology·Amer Al-KhoujaGilbert J Burckart
Apr 19, 2017·Journal of the Pediatric Infectious Diseases Society·Surabhi B VoraJanet A Englund
Nov 20, 2016·Folia Microbiologica·Daniele Zendrini RechenchoskiCarlos Nozawa
Jun 4, 2018·The Journal of Antimicrobial Chemotherapy·Nadège NeantPierre Frange
Oct 17, 2019·Biomolecules·Lana F ThaljehMichal Brylinski
Aug 23, 2020·International Journal of Molecular Sciences·Dong LiMin-Hua Luo
Nov 12, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Sanya J ThomasDebra J Lugo
Oct 10, 2020·Virology·Bratati Saha, Robin J Parks
Feb 13, 2021·Antiviral Research·Mackenzie J DodgeJoe S Mymryk
Nov 10, 2020·Journal of Clinical Pharmacy and Therapeutics·Thao K LeAmy L Kiskaddon
Aug 28, 2020·Microorganisms·Bratati Saha, Robin J Parks
Mar 26, 2021·Journal of Virology·Mahmoud S AlghamriKatherine J D A Excoffon
Jun 28, 2021·Bioorganic Chemistry·Sarah MazzottaJavier Sánchez-Céspedes
Jul 30, 2021·The Journal of Antimicrobial Chemotherapy·Anat SternDionysios Neofytos
Sep 14, 2021·Clinical Transplantation·Aditya ChandorkarJose F Camargo