The pharmacokinetics and serum bactericidal activity of vancomycin alone and in combination with ceftazidime were investigated in 10 healthy volunteers. The pharmacokinetic parameters showed no significant differences (P less than 0.05) between single and combined administration. No antagonistic effects were observed in serum bactericidal activity with the combination against 20 gram-positive and 20 gram-negative locally isolated bacteria. A titer of greater than or equal to 1:8 was generated by the combination against all test strains except enterococci. Seven of ten volunteers developed a typical "red man's syndrome" during the administration of 1.0 g of vancomycin.
Serum dilution test for bactericidal activity. II. Standardization and correlation with antimicrobial assays and susceptibility tests
Comparison of steady-state pharmacokinetics of two dosage regimens of vancomycin in normal volunteers
Significance of serum bactericidal activity in gram-negative bacillary bacteremia in patients with and without granulocytopenia
Hemofiltrability of histamine H2-receptor antagonist, nizatidine, and its metabolites in patients with renal failure
Evaluating aztreonam and ceftazidime pharmacodynamics with Escherichia coli in combination with daptomycin, linezolid, or vancomycin in an in vitro pharmacodynamic model
Pharmacokinetics and serum bactericidal activities of quinolones in combination with clindamycin, metronidazole, and ornidazole
Vancomycin hypersensitivity: synergism with narcotics and "desensitization" by a rapid continuous intravenous protocol
Using a Vancomycin PBPK Model in Special Populations to Elucidate Case-Based Clinical PK Observations
Is Antimicrobial Treatment Effective During Therapeutic Plasma Exchange? Investigating the Role of Possible Interactions
CRISPR Screens in Drug Resistance
CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.