PMID: 6168847Sep 1, 1981Paper

Pharmacokinetics and serum concentration--effect relationship of intravenous deslanoside

Journal of Cardiovascular Pharmacology
O M BakkeE Lien

Abstract

The antibodies of two commercially available digoxin-radioimmunoassay kits showed complete equimolar cross-reactivity with deslanoside and were used to determine serum levels of the latter glycoside. The serum concentrations of deslanoside were measured after a single intravenous dose of 1.2 mg in four patients recuperating after acute myocardial infarction. A phase of log-linear elimination (pseudoequilibrium) was reached after 4--8 h, and the biological half-life was 38-77 h (median 51 h). In a second study, the serum concentration was determined daily in 15 patients given multiple intravenous doses of the drug for atrial fibrillation and/or congestive heart failure. Symptoms or signs of digitalis toxicity occurred in six patients given a loading dose of deslanoside followed by daily maintenance doses of 0.4--0.6 mg. One of the patients tolerated a steady-state serum concentration of 3.9 micrograms/L (4.1 nmol/L) without toxicity symptoms. The findings in the remaining 14 patients suggest that the upper limit of the "therapeutic" concentration range is approximately 2.5 micrograms/L (2.7 nmol/L). A significant positive correlation (p less than 0.001) was found between the serum concentration of the drug and serum creatinine. ...Continue Reading

Citations

Aug 30, 2003·International Immunopharmacology·Maria Imaculada Muniz-JunqueiraLuiz Fernando Junqueira
Dec 2, 2005·Pharmacology·Yu Nan ZhaoLi Jun Du

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