Abstract
To examine whether systemic beta2-adrenoceptor responses, such as tachycardia, tremor and hypokalaemia, can be used as a surrogate for the 20 min pharmacokinetic profile of inhaled salbutamol. A retrospective analysis of eight separate published studies in healthy volunteers was performed, each with an identical protocol evaluating the early lung absorption profile of a nominal 1200 microg dose of salbutamol given by different inhaler devices. Peak postural finger tremor, plasma potassium and heart rate were assessed. We found the maximum (Cmax) and average (Cav) plasma concentrations of salbutamol to be correlated (P < 0.0001) to change in plasma potassium (Cmax r = 0.904; Cav r = 0.899) and tremor (Cmax r = 0.875; Cav r = 0.857). No significant correlations existed between change in heart rate and Cmax (r = 0.425) or Cav (r = 0.415). Systemic beta2-adrenoceptor responses, in particular hypokalaemia and tremor, but not heart rate, appear to be good surrogates for evaluating the lung delivery of inhaled salbutamol. Consequently it is suggested that potassium or tremor responses may be used to evaluate the relative lung delivery of salbutamol from different inhaler devices.
References
Jan 1, 1989·European Journal of Clinical Pharmacology·B J Lipworth, D G McDevitt
Sep 1, 1989·Circulation Research·J A HallM J Brown
Aug 1, 1983·British Journal of Clinical Pharmacology·J M Arnold, D G McDevitt
Jun 1, 1996·Thorax·H ChrystynV Silkstone
Mar 1, 1996·Thorax·D J ClarkB J Lipworth
Mar 1, 1996·British Journal of Clinical Pharmacology·D J Clark, B J Lipworth
Dec 1, 1996·British Journal of Clinical Pharmacology·B J Lipworth
Oct 1, 1996·Thorax·D J Clark, B J Lipworth
Jan 1, 1997·Clinical Pharmacokinetics·D J Clark, B J Lipworth
Aug 1, 1997·The European Respiratory Journal·B J Lipworth, D J Clark
Jan 1, 1997·European Journal of Clinical Pharmacology·B J Lipworth, D J Clark
Mar 10, 1998·British Journal of Clinical Pharmacology·B J Lipworth, D J Clark
Mar 28, 1998·Thorax·B J Lipworth, D J Clark
Aug 5, 1998·British Journal of Clinical Pharmacology·B J Lipworth, D J Clark
Aug 1, 1997·Pulmonary Pharmacology & Therapeutics·B J Lipworth, D J Clark
Citations
Jan 24, 2004·Behavioural Brain Research·Pedro C ElíasEdgardo O Alvarez
Oct 5, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Brian J LipworthBrian J O'Connor
Jun 22, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Pierre-Olivier Girodet, Mathieu Molimard
Dec 21, 2004·British Journal of Clinical Pharmacology·Brian J LipworthRobert Fishman
Jun 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·M D LakieN Langford
Jun 20, 2015·Frontiers in Pharmacology·Karan ThakkarRajen Shah
Jan 10, 2009·The Journal of Allergy and Clinical Immunology·Brian J Lipworth, Karine Clearie
Jun 23, 2010·British Journal of Clinical Pharmacology·Karine L ClearieBrian J Lipworth
Jan 18, 2011·European Journal of Clinical Pharmacology·Arun NairBrian J Lipworth
Sep 14, 2019·The European Respiratory Journal·Paul BrinkmanUNKNOWN U-BIOPRED Study Group
Sep 25, 2010·Journal of Applied Physiology·Cecilia McCormickGabriel Mutungi
Nov 15, 2011·British Journal of Clinical Pharmacology·Philip M ShortBrian J Lipworth
Jan 4, 2012·Biomedical Chromatography : BMC·Dujuan ZhangRuichen Guo
Jul 21, 2021·Journal of Equine Veterinary Science·Kate Loomes