PMID: 8588222Dec 1, 1995Paper

Pharmacokinetics and therapeutic drug monitoring of immunosuppressants

Therapeutic Drug Monitoring
A Lindholm, J Säwe

Abstract

Immunosuppressive drug treatment has developed considerably in recent years with new methods describing pharmacokinetic-pharmacodynamic relationships. Using in vitro models it is possible to predict the success of clinical immunosuppressive drug combinations. Furthermore, with the advances of analytical methodology it is now possible to measure minute amounts of potent immunosuppressants and to adjust dosing based on concentration measurements. Concentration control, which first was required for cyclosporine A, is being investigated for most immunosuppressive drugs in development. Characterisation of individual drug pharmacokinetics form the basis for successful immunosuppression. Among possible therapeutic drug monitoring methodologies, trough level monitoring is currently the method of choice.

Citations

Dec 17, 2010·European Journal of Clinical Pharmacology·Bing ChenWeiMin Cai
Mar 26, 2004·Transplantation Proceedings·M H KapturczakB Kaplan
May 20, 1999·Transplantation Proceedings·U Christians
Apr 16, 2002·Clinical Therapeutics·Barry D KahanAtholl Johnston
Nov 8, 2001·Journal of Clinical Pharmacology·M H MageeW J Jusko
Jun 8, 2000·Clinical Pharmacokinetics·R J Dumont, M H Ensom
Aug 23, 2002·Clinical Pharmacokinetics·Uwe ChristiansAlfonso Lampen
Feb 19, 2015·International Journal of Molecular Sciences·Gianluigi ZazaAntonio Lupo
Nov 21, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B ChenW Cai
Feb 14, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Dario CattaneoGiuseppe Remuzzi
Dec 9, 2009·Clinical and Experimental Immunology·G ZazaF P Schena
Jan 28, 2006·European Journal of Pharmacology·Makoto OkadaNoriyasu Fujioka
May 26, 2018·Transplantation Direct·Chetan NaikMatthew Morrell
Sep 5, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dušan KrnáčBoris Rolinski

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