Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yun-ru Peng, Yong-fang Ding

Abstract

Caudatin is a potential antitumor agent isolated from the traditional Chinese medicine "baishouwu", which was the root tuber of Cynanchum auriculatum Royle ex Wight. In our previous studies, caudatin showed selectivity on human hepatoma cell line SMMC7721 among several different tumor cell lines, and further in vivo tests validated the inhibitory action of caudatin against hepatic cancer using an H22 solid tumor model in mice, but to our knowledge, the biopharmaceutical properties of caudatin are largely unknown. In this study, a simple, rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of caudatin in rat plasma and tissues, which kept the run time to detect one sample within 4 min, was developed and validated. Pharmacokinetics and tissue distribution studies of caudatin in conventional rats and hepatocellular carcinoma (HCC) model rats were then conducted for the first time. Statistically significant differences were observed between conventional rats and diethylnitrosamine (DEN)-induced HCC rats with respect to pharmacokinetic parameters, including maximum concentration (Cmax), time to reach Cmax (Tmax), half-life (t1/2), area under the concentration...Continue Reading

References

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Citations

Feb 27, 2017·Journal of Cancer Research and Clinical Oncology·Yong-Fang DingYun-Ru Peng
Aug 1, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ashok IyaswamyMin Li
Sep 3, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shuai QiuHong Jin Lee

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BETA
pharmacotherapy

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DAS

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