Pharmacokinetics and tissue tolerance of azithromycin after intramuscular administration to rabbits

Research in Veterinary Science
Elisa EscuderoCarlos M Cárceles

Abstract

The pharmacokinetics of azithromycin after intravenous and intramuscular injection at a single dose rate of 10mg/kg bodyweight were investigated in rabbits by using a modified agar diffusion bioassay for determining plasma concentrations. The plasma creatine kinase activity was determined after i.m. administration for the evaluation of the tissue tolerance. The elimination half-lives of azithromycin after intravenous and intramuscular administration were 24.1 and 25.1h, respectively. After intramuscular administration mean peak plasma concentration was 0.26+/-0.01 mg/L and bioavailability was 97.7%. Plasma CK activity rose sharply within 8h after i.m. injection of azithromycin; activity returned to pre-treatment level by 48-72 h post-treatment. The transient rise in serum CK activity indicates some degree of muscle tissue damage at the injection site.

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Mar 15, 2006·Research in Veterinary Science·E EscuderoC M Cárceles

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Citations

Aug 15, 2006·The Veterinary Journal·Carlos M CárcelesElisa Escudero
Mar 15, 2006·Research in Veterinary Science·E EscuderoC M Cárceles

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