Pharmacokinetics and toxicity of two modalities of etoposide infusion in metastatic non-small-cell lung carcinoma

Cancer Chemotherapy and Pharmacology
E ChatelutR Bugat

Abstract

The pharmacokinetics and toxicity of two schedules of etoposide administration were studied in 19 patients suffering from metastatic non-small-cell lung cancer. Ten subjects received a 72-h continuous venous infusion (CVI) of 360 mg/m2 etoposide, and nine were given a daily dose of 120 mg/m2 for 3 consecutive days. In the two groups 80 mg/m2 cis-diamminedichloroplatinum (II) (CDDP) was infused on day 1. With CVI, the steady-state plasma concentration was reached 12-24 h after the start of the treatment. The plasma elimination rate showed a biexponential decay curve in both groups. No significant difference between total body clearance and the beta-phase volume of distribution was noted between the two modalities of administration. No relationship was found between biological and pharmacokinetic parameters.

References

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Related Concepts

Antineoplastic Chemotherapy Protocols
Non-Small Cell Lung Carcinoma
Platinol
Drug Administration Schedule
Drug Evaluation
Riboposid
Intravenous Infusion Procedures
Leukopenia
Malignant Neoplasm of Lung
Total Body Clearance Rate

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