Abstract
The pharmacokinetics and bioavailability of cefquinome in Beagle dogs were determined by intravenous (IV), intramuscular (IM) or subcutaneous (SC) injection at a single dose of 2 mg/kg body weight (BW). The minimum inhibitory concentrations (MIC) of cefquinome against 217 Escherichia coli isolated from dogs were also investigated. After IV injection, the plasma concentration-time curve of cefquinome was analyzed using a two-compartmental model, and the mean values of t1/2α (h), t1/2β (h), Vss (L/kg), ClB (L/kg/h) and AUC (μg·h/mL) were 0.12, 0.98, 0.30, 0.24 and 8.51, respectively. After IM and SC administration, the PK data were best described by a one-compartmental model with first-order absorption. The mean values of t1/2Kel , t1/2Ka , tmax (h), Cmax (μg/mL) and AUC (μg·h/mL) were corresponding 0.85, 0.14, 0.43, 4.83 and 8.24 for IM administration, 0.99, 0.29, 0.72, 3.88 and 9.13 for SC injection. The duration of time that drug levels exceed the MIC (%T > MIC) were calculated using the determined MIC90 (0.125 μg/mL) and the PK data obtained in this study. The results indicated that the dosage regimen of cefquinome at 2 mg/kg BW with 12-h intervals could achieve %T > MIC above 50% that generally produced a satisfactory bacter...Continue Reading
References
Apr 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Jan 1, 1991·Antimicrobial Agents and Chemotherapy·M LimbertE Schrinner
May 1, 1995·Diagnostic Microbiology and Infectious Disease·W A Craig
Aug 1, 1995·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·A BöttnerR Humke
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·J A OrdenR De La Fuente
Dec 17, 2004·Journal of Veterinary Pharmacology and Therapeutics·P L Toutain, A Bousquet-Mélou
Dec 17, 2004·Journal of Veterinary Pharmacology and Therapeutics·P L Toutain, P Lees
Oct 8, 2008·Antimicrobial Agents and Chemotherapy·Christiane GaudreauSadjia Bekal
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·X B LiJ Z Shen
Feb 28, 2009·Journal of Fish Diseases·K M Brooks
Nov 26, 2010·Antimicrobial Agents and Chemotherapy·Kamil UneyMuammer Elmas
Jan 5, 2011·American Journal of Veterinary Research·Liguo YuanYahong Liu
May 28, 2011·Journal of Veterinary Pharmacology and Therapeutics·Y H HwangH I Yun
Aug 11, 2012·The Journal of Veterinary Medical Science·In Bae SongHyo In Yun
Nov 30, 2012·Journal of Veterinary Pharmacology and Therapeutics·D H ZhaoY H Liu
Mar 5, 2013·Tropical Animal Health and Production·Venkatathalam DinakaranPritam Kaur Sidhu
Jan 16, 2014·The Veterinary Journal·B X ZhangH Z Ding
Mar 13, 2014·Antimicrobial Agents and Chemotherapy·Jing WangZhenling Zeng
Citations
Jan 19, 2016·Frontiers in Microbiology·Yu-Feng ZhouYa-Hong Liu
Sep 30, 2016·Journal of Veterinary Pharmacology and Therapeutics·Q Shan, J Wang
Nov 11, 2016·BMC Veterinary Research·Yafei LiZhenling Zeng
May 25, 2016·PloS One·Yang YuYa-Hong Liu
Mar 8, 2017·Antimicrobial Agents and Chemotherapy·Yu-Feng ZhouYa-Hong Liu
Apr 14, 2018·Drug Delivery·Shaoqi QuZhihui Hao
Oct 17, 2017·Frontiers in Pharmacology·Yu-Feng ZhouXiao-Ping Liao
Mar 30, 2019·Pharmaceutical Research·Shaoqi QuYanping Zhang
Aug 12, 2020·Journal of Veterinary Pharmacology and Therapeutics·Nicolás Javier LitterioJuan Manuel Serrano-Rodríguez
Jul 30, 2017·BMC Veterinary Research·Dong-Hao ZhaoLiu-Dong Li
Oct 28, 2020·American Journal of Veterinary Research·Peng ChengHongwei Chen
May 10, 2020·Acta Veterinaria Hungarica·Abdullah AltaybanMohammed Al-Nazawi