PMID: 3921586May 1, 1985

Pharmacokinetics, bioavailability and serum levels of cardiac glycosides

Journal of the American College of Cardiology
T W Smith

Abstract

Digoxin, the cardiac glycoside most frequently used in clinical practice in the United States, can be given orally or intravenously and has an excretory half-life of 36 to 48 hours in patients with serum creatinine and blood urea nitrogen values in the normal range. Since the drug is excreted predominantly by the kidney, the half-life is prolonged progressively with diminishing renal function, reaching about 5 days on average in patients who are essentially anephric. Serum protein binding of digoxin is only about 20%, and differs markedly in this regard from that of digitoxin, which is 97% bound by serum albumin at usual therapeutic levels. Digitoxin is nearly completely absorbed from the normal gastrointestinal tract and has a half-life averaging 5 to 6 days in patients receiving usual doses irrespective of renal function. The bioavailability of digoxin is appreciably less than that of digitoxin, averaging about two-thirds to three-fourths of the equivalent dose given intravenously in the case of currently available tablet formulations. Recent studies have shown that gut flora of about 10% of patients reduce digoxin to a less bioactive dihydro derivative. This process is sensitive to antibiotic administration, creating the pot...Continue Reading

References

May 1, 1977·Clinical Pharmacokinetics·M Weintraub
Sep 1, 1978·Progress in Cardiovascular Diseases·J E DohertyM L Murphy
Jan 1, 1976·Clinical Pharmacokinetics·D J GreenblattJ Koch-Weser
Jul 1, 1977·Clinical Pharmacokinetics·D PerrierF I Marcus
May 1, 1985·Journal of the American College of Cardiology·F I Marcus
May 1, 1985·Journal of the American College of Cardiology·B Surawicz
Apr 5, 1973·The New England Journal of Medicine·T W Smith
Sep 1, 1972·European Journal of Pharmacology·A HaassT Peters
Nov 16, 1972·The New England Journal of Medicine·M C RogersT W Smith
Nov 20, 1972·JAMA : the Journal of the American Medical Association·D H Huffman, D L Azarnoff
Mar 1, 1973·The American Journal of Cardiology·J K BissettG V Dalrymple
Mar 1, 1974·Circulation·J G HarterA W Steers
Jul 1, 1974·Circulation·E Steiness
Sep 1, 1972·The Journal of Pediatrics·R W KrasulaL F Soyka
Feb 1, 1972·American Heart Journal·H M Solomon, W B Abrams
Jul 29, 1971·The New England Journal of Medicine·W D HeizerS E Goldfinger
Nov 1, 1971·Circulation·G A EwyF I Marcus
Nov 27, 1969·The New England Journal of Medicine·T W SmithE Haber
Aug 22, 1970·British Medical Journal·D A ChamberlainT W Smith
May 6, 1971·The New England Journal of Medicine·G A BellerW B Hood
Aug 1, 1968·The American Journal of Medicine·R J Luchi, J W Gruber
Jun 1, 1969·The Journal of Clinical Investigation·D S Lukas, A G De Martino
Jul 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
May 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Mar 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Oct 1, 1981·The New England Journal of Medicine·J LindenbaumJ R Saha

Citations

Dec 1, 1991·Journal of Ethnopharmacology·M J Groves, N G Bisset
Mar 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A M HoD D Suria
Sep 30, 2014·European Journal of Pharmacology·Elnaz GozalpourJan B Koenderink
Jun 6, 1994·The American Journal of Medicine·W R GarnettG Dimenna
Jul 18, 2002·The American Journal of the Medical Sciences·Roya M SameriTimothy H Self
Aug 1, 1988·Journal of Clinical Pharmacology·A Ohnishi, T Ishizaki
Aug 22, 2018·Expert Opinion on Investigational Drugs·Yu-Long LanBo Zhang
Mar 1, 1996·Cardiovascular Drugs and Therapy·A MillaireG Ducloux
Feb 24, 2001·Drugs & Aging·C G HanrattyA P Passmore
Aug 30, 2001·European Journal of Clinical Investigation·G G BelzU Osowski
Mar 13, 2010·American Journal of Therapeutics·Mayank K MittalAnand Chockalingam
Feb 11, 1988·The New England Journal of Medicine·T W Smith
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·W Schoner
Jan 1, 1986·Acta Medica Scandinavica·L Mogensen

Related Concepts

Process of Absorption
Cardiac Glycosides
Cost Effectiveness
Digitoxin-Philo
Mapluxin
Half-Life
Radioimmunoassay

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.