Pharmacokinetics, metabolism, and carcinogenicity of arsenic

Reviews of Environmental Contamination and Toxicology
W A PottR S Yang

Abstract

The carcinogenicity of arsenic in humans has been unambiguously demonstrated in a variety of epidemiological studies encompassing geographically diverse study populations and multiple exposure scenarios. Despite the abundance of human data, our knowledge of the mechanism(s) responsible for the carcinogenic effects of arsenic remains incomplete. A deeper understanding of these mechanisms is highly dependent on the development of appropriate experimental models, both in vitro and in vivo, for future mechanistic investigations. Suitable in vitro models would facilitate further investigation of the critical chemical species (arsenate/arsenite/MMA/DMA) involved in the carcinogenic process, as well as the evaluation of the generation and role of ROS. Mechanisms underlying the clastogenic effects of arsenic, its role in modulating DNA methylation, and the phenomenon of inducible tolerance could all be more completely investigated using in vitro models. The mechanisms involved in arsenic's inhibition of ubiquitin-mediated proteolysis demand further attention, particularly with respect to its effects on cell proliferation and DNA repair. Exploration of the mechanisms responsible for the protective or anticarcinogenic effects of arsenic ...Continue Reading

Citations

Sep 2, 2004·Analytical and Bioanalytical Chemistry·Andrea Raab, J Feldmann
Sep 1, 2005·Molecular and Cellular Biochemistry·Sung Gu HanVal Vallyathan
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Angeline S AndrewJoshua W Hamilton
Sep 10, 2010·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Tsutomu NishimuraTamio Maitani
Sep 7, 2013·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Sham K WadhwaDemirhan Citak
Oct 7, 2015·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Amr A FouadIyad Jresat
May 8, 2019··S. R. SatoneAditi L. Tulankar

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