Pharmacokinetics of β-Alanine Using Different Dosing Strategies

Frontiers in Nutrition
Jan StautemasWim Derave

Abstract

Introduction: The ergogenic response following long-term ingestion of β-alanine shows a high inter-individual variation. It is hypothesized that this variation is partially caused by a variable pharmacokinetic response induced by inferior dosing strategies. At this point most supplements are either taken in a fixed amount (× g), as is the case with β-alanine, or relative to body weight (× g per kg BW), but there is currently neither consensus nor a scientific rationale on why these or other dosing strategies should be used. The aim of this study is to objectify and understand the variation in plasma pharmacokinetics of a single oral β-alanine dose supplemented as either a fixed or a weight-relative dose (WRD) in an anthropometric diverse sample. Methods: An anthropometric diverse sample ingested a fixed dose (1,400 mg) (n = 28) and a WRD of β-alanine (10 mg/kg BW) (n = 34) on separate occasions. Blood samples were taken before and at nine time points (up to 4 h) after β-alanine ingestion in order to establish a pharmacokinetic profile. Incremental area under the curve (iAUC) was calculated by the trapezoidal rule. Plasma β-alanine was quantified using HPLC-fluorescence. Results: The variation coefficient (CV%) of the iAUC was 3...Continue Reading

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Citations

Apr 14, 2019·Advances in Nutrition·Eimear DolanBruno Gualano
Oct 10, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Peter PeelingLouise M Burke
Sep 12, 2019·Frontiers in Nutrition·Pedro PerimBryan Saunders
Dec 20, 2018·Journal of the International Society of Sports Nutrition·Liam BeasleyJustin Roberts

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Software Mentioned

SPSS
Statistical Package for the Social Sciences

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