PMID: 8453687Jan 1, 1993Paper

Pharmacokinetics of (1R,2R-diaminocyclohexane)oxalatoplatinum(II) in comparison with cisplatin following a single intravenous injection in rabbits

Cancer Chemotherapy and Pharmacology
R KizuM Miyazaki

Abstract

The pharmacokinetics of (1R,2R-diaminocyclohexane)oxalatoplatinum(II) (1-OHP, NSC-266046), a second-generation antitumor platinum complex, was studied in rabbits and compared with that of cisplatin. The rabbits were given a single i.v. dose of 1-OHP or cisplatin (10 mumol/kg). A comparison of tissue platinum levels at 24 h postinjection showed that platinum levels were lower in the eight organs examined, which included the kidney and liver, after the injection of 1-OHP than following cisplatin administration. Plasma-decay profiles of three platinum species, that is, the unchanged species, filterable platinum, and total platinum, were examined. Plasma levels of the unchanged species and filterable platinum for 1-OHP declined more rapidly than those for cisplatin. The ratio of plasma filterable-to-total platinum indicated that the protein-binding ability of 1-OHP was greater than that of cisplatin. As for urinary excretion, amounts of the unchanged species and total platinum excreted during the 24 h period postinjection were 28% and 76% of the dose for 1-OHP and 23% and 57% of the dose for cisplatin, respectively. The renal clearance of both the unchanged species and filterable platinum in plasma for 1-OHP was about 2-fold that f...Continue Reading

References

Mar 1, 1979·Clinical Pharmacology and Therapeutics·P E GormleyR Cysyk
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·B J FosterB Leyland-Jones
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·J M ExtraM Marty
Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·T TashiroY Kidani
Jan 1, 1988·Cancer Chemotherapy and Pharmacology·Z H SiddikK R Harrap
Jan 1, 1986·Cancer Chemotherapy and Pharmacology·W J van der Vijgh, I Klein
Jun 1, 1985·Cancer Letters·G MathéE Chenu
Jan 1, 1984·Annals of Internal Medicine·R F OzolsR C Young
May 1, 1984·Annals of Internal Medicine·P J Loehrer, L H Einhorn
Apr 1, 1983·Journal of Chromatographic Science·I S KrullL A Sternson
May 1, 1980·Chemico-biological Interactions·W C Cole, W Wolf
May 1, 1981·Clinical Pharmacology and Therapeutics·K J HimmelsteinL A Sternson
Nov 1, 1981·Journal of Pharmacobio-dynamics·K YamaokaT Uno

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Citations

Feb 11, 2000·Clinical Pharmacokinetics·F LéviG Milano
Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Anna CividalliDonatella Tirindelli Danesi
Jun 24, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hironobu YanagieMasazumi Eriguchi
Nov 16, 2014·Cancer Chemotherapy and Pharmacology·Julie L EisemanCharles C Horn

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