PMID: 7334459Oct 1, 1981Paper

Pharmacokinetics of 2-butanol and its metabolites in the rat

Journal of Pharmacokinetics and Biopharmaceutics
F K DietzK J Himmelstein

Abstract

A pharmacokinetic model is presented to describe the biotransformation of 2-butanol (2-OL) and its metabolites (2-butanone, 3-hydroxy-2-butanone, and 2, 3-butanediol) using in vivo experimental blood concentration. A flow limited model is developed to simulate 2-OL, 2-butanone (2-ONE), 3-hydroxy-2-butanone (3H-2B), and 2,3-butanediol (2,3-RD) blood concentrations in rats after oral administration of 2-OL. Assuming the only important site of 2-OL biotransformation is the liver, the tissues included are the liver and a volume of distribution, essentially body water in the case of 2-OL and its metabolites. A distribution coefficient is found to be necessary to describe the low concentration of 3H-2B in blood after administration of 2-OL. The need for this coefficient may be due to partitioning, binding, or altered transport rates from the liver. Inhibition of 2-ONE metabolism to 3H-2B by 2-OL has been included to explain a time delay in the appearance of 3H-2B after administration of 2-OL. Subsequent experimental verification confirms the mixed function oxidase inhibitory properties of 2-OL. The model is able to simulate blood concentrations and elimination of all four compounds after the oral administration of 2-OL. Additionally,...Continue Reading

References

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Citations

Jan 1, 1988·International Archives of Occupational and Environmental Health·J LiiraP Pfäffli
Feb 1, 1990·Toxicology Letters·J LiiraV Riihimäki
Jul 23, 2002·Journal of Toxicology and Environmental Health. Part a·Karla D ThrallAngela D Woodstock
May 1, 1990·British Journal of Industrial Medicine·J LiiraK Engström
Jan 10, 2002·Journal of Pharmaceutical Sciences·Patrick Poulin, Frank-Peter Theil
Feb 26, 2008·Regulatory Toxicology and Pharmacology : RTP·Dirk W LachenmeierKatja Schulz
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Dec 1, 1984·Toxicology and Applied Pharmacology·E M Brown, W R Hewitt
Apr 21, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M SaillenfaitA M Lambert
Jul 28, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Hiroyuki OkamuraTamio Maitani
Jan 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J LiiraK Engström
Jun 22, 2017·Drug and Chemical Toxicology·Frédéric CosnierPierre Campo

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