Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Suzanna ZickDean E Brenner

Abstract

Ginger shows promising anticancer properties. No research has examined the pharmacokinetics of the ginger constituents 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in humans. We conducted a clinical trial with 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol, examining the pharmacokinetics and tolerability of these analytes and their conjugate metabolites. Human volunteers were given ginger at doses from 100 mg to 2.0 g (N = 27), and blood samples were obtained at 15 minutes to 72 hours after a single p.o. dose. The participants were allocated in a dose-escalation manner starting with 100 mg. There was a total of three participants at each dose except for 1.0 g (N = 6) and 2.0 g (N = 9). No participant had detectable free 6-gingerol, 8-gingerol, 10-gingerol, or 6-shogaol, but 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol glucuronides were detected. The 6-gingerol sulfate conjugate was detected above the 1.0-g dose, but there were no detectable 10-gingerol or 6-shogaol sulfates except for one participant with detectable 8-gingerol sulfate. The C(max) and area under the curve values (mean +/- SE) estimated for the 2.0-g dose are 0.85 +/- 0.43, 0.23 +/- 0.16, 0.53 +/- 0.40, and 0.15 +/- 0.12 microg/mL; and 65.6.33 +/-...Continue Reading

References

Dec 1, 1992·Japanese Journal of Cancer Research : Gann·N YoshimiH Mori
Jun 1, 1991·Chemical & Pharmaceutical Bulletin·G H DingK Iwamoto
Dec 20, 1999·Journal of Agricultural and Food Chemistry·J M KuoB S Pan
Feb 26, 2000·Journal of Agricultural and Food Chemistry·Y SekiwaA Kobayashi
Apr 14, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R S AhmedB D Banerjee
Dec 18, 2001·Journal of Pharmaceutical Sciences·S BhattaraiC C Duke
May 11, 2002·Life Sciences·Takahiro Nakazawa, Keisuke Ohsawa
May 4, 2004·International Journal of Cancer. Journal International Du Cancer·Akira MurakamiHajime Ohigashi
Oct 19, 2004·Cancer Letters·Thambi Dorai, Bharat B Aggarwal
Jul 16, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vaiyapuri Manju, Namasivayam Nalini
Aug 6, 2005·Biochemical and Biophysical Research Communications·Eok-Cheon KimYoung-Guen Kwon
Aug 25, 2005·Journal of Medicinal Food·Reinhard GrzannaCarmelita G Frondoza
Oct 1, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S ChrubasikB D Roufogalis
May 20, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R C LantzB N Timmermann
Jan 18, 2007·Journal of Agricultural and Food Chemistry·Erika PfeifferManfred Metzler
Aug 21, 2007·Biochemical and Biophysical Research Communications·Kazuhiro IshiguroHidemi Goto

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Citations

Mar 20, 2010·Journal of Natural Medicines·Akitoshi AsamiMasaki Aburada
Aug 19, 2011·The British Journal of Nutrition·Prasanthi KarnaRitu Aneja
Jun 19, 2013·Acta Pharmacologica Sinica·Mian LiHui Wang
Feb 28, 2013·Nutrition and Cancer·Meera BrahmbhattRitu Aneja
May 18, 2012·Critical Reviews in Food Science and Nutrition·I Rahath Kubra, L Jagan Mohan Rao
Jun 1, 2010·Midwives·Denise Tiran
Jan 17, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Huadong ChenShengmin Sang
Feb 7, 2012·Cancer Prevention Research·Jed W FaheyThomas W Kensler
Oct 16, 2012·American Journal of Respiratory Cell and Molecular Biology·Elizabeth A TownsendCharles W Emala
Dec 8, 2011·Journal of Neurogastroenterology and Motility·Seng-Kee ChuahChi-Sin Changchien
Apr 10, 2014·BMC Complementary and Alternative Medicine·Wolfgang MarxLiz Isenring
Jun 6, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Khairunnisa' Md YusofWan Zurinah Wan Ngah
Jan 23, 2014·Journal of Agricultural and Food Chemistry·Renaud F WarinShengmin Sang
Feb 10, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Wei WangLian-Wen Qi
Aug 1, 2015·Phytochemistry·Ruchi Badoni SemwalAlvaro M Viljoen
Aug 19, 2015·Phytotherapy Research : PTR·Jae-Sun ChoiJoo-Won Jeong
Jan 17, 2013·Molecular Nutrition & Food Research·Huadong ChenShengmin Sang
Jun 7, 2013·The Journal of Pharmacy and Pharmacology·Gregory S GormanBethany Rasberry
Mar 17, 2010·BioFactors·Ademola A OyagbemiOdunayo I Azeez
Sep 17, 2013·Molecular Nutrition & Food Research·Amanda VillalvillaRodolfo Gómez
Aug 8, 2015·Chemical Research in Toxicology·Yingdong ZhuShengmin Sang
Sep 18, 2012·Vascular Pharmacology·Andreas LeihererHeinz Drexel

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