Pharmacokinetics of 99mTc-MAA and 99mTc-HSA-Microspheres used in pre-Radioembolization Dosimetry - Influence on the Liver-Lung Shunt

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Oliver S GrosserHolger Amthauer

Abstract

Perfusion scintigraphy (PS) using technetium-99m ((99m)Tc) labeled albumin-aggregates is a mandatory step before hepatic radioembolization (RE) with yttrium-90-labeled microspheres. Within the bounds of a prospective clinical trial, this sub-analysis assessed the intrahepatic and intrapulmonary stability of two albumin-compounds, (99m)Tc-MAA (macroaggregated serum albumin, MAA) and (99m)Tc-HSA (human serum albumin, HSA) after intra-arterial injection. In n = 24 patients (age: 64.6y: 46.2-82.2) with metastatic colorectal cancer (mCRC), PS-data of both tracers were analyzed (n = 12 patients each). Biodistribution (liver, lung) and liver-lung shunt (LLS) was assessed by sequential planar scintigraphy (1h, 5h and 24h post intra-hepatic/intra-arterial injection; p.i.) using the region of interest (ROI) technique. Data were corrected for radioactive decay. Liver uptake of MAA decreased significantly from 1h (median particle uptake=70.0%) to 5h (45.5%, p<0.0001) and 24h (27.9%, p<0.0001), respectively. MAA-uptake in the lungs at first increased significantly from 1h (2.7%) to 5h (3.8%, P = 0.0007) and then decreased significantly from 5h to 24h (3.0%, P = 0.002). HSA-uptake in the liver decreased significantly from 1h (70.2%) to 5h (6...Continue Reading

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Citations

Nov 6, 2018·EJNMMI Physics·Remco BastiaannetHugo W A M de Jong
Jan 5, 2021·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·S Cheenu KappadathMarnix G Lam
Jan 27, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Helmut DittmannChristian la Fougère
Oct 12, 2021·EJNMMI Radiopharmacy and Chemistry·Ruslan CusnirMarietta Straub

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