Pharmacokinetics of a loading dose of intravenous paracetamol post caesarean delivery

International Journal of Obstetric Anesthesia
A KuloKarel Allegaert

Abstract

The postpartum period affects drug disposition, but data of intravenous paracetamol loading dose pharmacokinetics immediately following caesarean delivery have not yet been reported. Immediately following caesarean delivery, women received a 2-g loading dose of intravenous paracetamol. Plasma samples were collected at 1, 2, 4 and 6 h. Individual pharmacokinetics were calculated assuming a linear one-compartment model with instantaneous input and first-order output. Data were reported using median and range. Twenty-eight patients undergoing caesarean delivery were recruited (age 31.5 [20-42] years, weight 79 [57-110] kg, body surface area 1.9 [1.5-2.4]m(2)). Median paracetamol plasma concentrations after 1, 2, 4 and 6 h were 22.5, 15.25, 7.9, and 3.9 mg/L respectively. Paracetamol clearance was 20.3 (11.8-62.8) L/h or 10.9 (7-23.8)L/hm(2), distribution volume 58.3 (42.9-156) L or 0.72 (0.52-1.56) L/kg. Pharmacokinetics of intravenous paracetamol have been estimated following caesarean delivery. Although limited to a loading dose shortly after surgery, the results are clinically relevant since this is the first description in this patient population. These data provide evidence on which to base further integrated pharmacokinetic/...Continue Reading

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Citations

Aug 21, 2012·International Journal of Obstetric Anesthesia·A KuloK Allegaert
Jun 8, 2012·Journal of Biomedicine & Biotechnology·Aida KuloKarel Allegaert
Aug 8, 2012·Journal of Anaesthesiology, Clinical Pharmacology·Aida KuloKarel Allegaert
Nov 20, 2013·Journal of Anaesthesiology, Clinical Pharmacology·Luana Mifsud BuhagiarLilian M Azzopardi
Aug 27, 2013·Clinics in Perinatology·Anne Lavoie, Paloma Toledo
Nov 17, 2015·BMC Anesthesiology·Karel AllegaertCatherijne A J Knibbe
Sep 1, 2012·European Journal of Anaesthesiology·Karel AllegaertMarc van de Velde
Aug 1, 2012·British Journal of Clinical Pharmacology·Aida KuloCatherijne A J Knibbe
Jan 20, 2021·Der Anaesthesist·Dorothee H Bremerich, Susanne Greve
Jan 17, 2021·American Journal of Obstetrics & Gynecology MFM·Shadi MehrabanNisha Lakhi

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