Pharmacokinetics of a new, orally available ceftriaxone formulation in physical complexation with a cationic analogue of bile acid in rats.

Antimicrobial Agents and Chemotherapy
Seulki LeeYoungro Byun

Abstract

Oral administration of ceftriaxone associated with a bile acid-based new oral carrier, cholylethylenediamine, in 50% propylene glycol to rats at doses of 25 and 50 mg/kg of body weight resulted in a significant increase in intestinal absorption, as evidenced by 55% improvement in the bioavailability, whereas ceftriaxone alone showed a bioavailability of less than 1%.

References

Jan 1, 1979·Reviews of Physiology, Biochemistry and Pharmacology·S Matern, W Gerok
May 26, 1992·Biochemistry·D W Russell, K D Setchell
Mar 1, 1985·Clinical Pharmacokinetics·L BalantR Auckenthaler
Mar 1, 1981·Antimicrobial Agents and Chemotherapy·H C NeuK P Fu
Dec 9, 1993·PharmacoEconomics·P Jewesson
Jun 1, 1999·The Journal of Antimicrobial Chemotherapy·F SevinçP Speelman
Jul 18, 2002·Accounts of Chemical Research·Xiao-Xia Zhu, Marieta Nichifor
Mar 23, 2004·Pharmaceutical Research·Robert G Strickley

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Citations

Jan 8, 2013·Pharmaceutical Research·Ok-Cheol JeonYoungro Byun
May 2, 2013·Journal of Proteome Research·Ying ZhaoYulan Wang
Dec 12, 2012·Advanced Drug Delivery Reviews·Taslim A Al-HilalYoungro Byun
Sep 4, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dong Yun LeeYoungro Byun
Jun 21, 2016·Advanced Drug Delivery Reviews·Sam MaherDavid J Brayden
Oct 24, 2018·Antimicrobial Agents and Chemotherapy·Boubakar BaTina Kauss
Jan 22, 2021·Pharmaceutical Development and Technology·Muhammad KawishMuhammad Raza Shah
Jul 28, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Feiyang Deng, You Han Bae
Nov 10, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Moritz MirnaMichael Lichtenauer

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