Pharmacokinetics of a single dose of intravenous and oral meloxicam in red-tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus)

Journal of Avian Medicine and Surgery
Claude LacasseDawn Merton Boothe

Abstract

Pharmacokinetic data were determined after a single dose of meloxicam in red-tailed hawks (RTH; Buteo jamaicensis) and great horned owls (GHO; Bubo virginianus). In a nonrandomized crossover design, individual birds of each species received 1 dose of intravenous meloxicam (0.5 mg/kg i.v.; n = 7 for each species) followed by a 2-week washout period, and then each received 1 dose of oral meloxicam (0.5 mg/kg PO; n = 5 for each species). Blood samples were collected intermittently after administration, and meloxicam was detected in plasma by high-performance liquid chromatography. Time versus plasma concentration data were subjected to noncompartmental analysis. Red-tailed hawks were determined to have the shortest elimination half-life for meloxicam (0.49 +/- 0.5 hours) of any species documented. Great horned owls also eliminated meloxicam very rapidly (0.78 +/- 0.52 hours). Great horned owls achieved higher plasma concentrations (368 +/- 87 ng/mL) of meloxicam than RTH (182 +/- 167 ng/mL) after oral administration, although RTH had a markedly higher volume of distribution (832 +/- 711 mL/kg) than GHO (137.6 +/- 62.7 mL/kg). The differences in meloxicam pharmacokinetics between these 2 raptor species supports the need for species...Continue Reading

References

Oct 1, 1978·Journal of Wildlife Diseases·E E Smith, M Bush
Mar 1, 1991·The British Veterinary Journal·P LeesU Busch
Jun 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·Bhavesh DasandiK M Bhat
Nov 14, 2002·American Journal of Veterinary Research·Steven C BudsbergAlice R Runk
Dec 18, 2002·Journal of Veterinary Pharmacology and Therapeutics·K Baert, P De Backer
Jan 14, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·K Baert, P De Backer
Mar 6, 2003·The Veterinary Clinics of North America. Exotic Animal Practice·Michael Lierz
Nov 2, 2004·Journal of the American Veterinary Medical Association·Kurt D Peterson, Thomas J Keefe
Nov 30, 2004·American Journal of Veterinary Research·Pierre-Louis ToutainRüdiger Narbe
Dec 29, 2005·Journal of the American Veterinary Medical Association·Adam D GasselBarton W Rohrbach
Jan 27, 2006·PLoS Biology·Gerry SwanKerri Wolter
Feb 23, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Dawn M ZimmermanMark G Papich
Apr 25, 2008·Journal of Clinical Pharmacology·Jules I SchwartzJohn A Wagner
Sep 3, 2011·Journal of Veterinary Pharmacology and Therapeutics·R A MosherB KuKanich

❮ Previous
Next ❯

Citations

Apr 19, 2016·Journal of Avian Medicine and Surgery·Dana M LindemannButch KuKanich
Oct 4, 2016·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Daniel V FredholmButch KuKanich
Feb 28, 2017·American Journal of Veterinary Research·Jennifer L BoonstraTomas Martin-Jimenez
Jun 15, 2018·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Andrea L Goodnight, Sherry Cox
Jun 16, 2018·Journal of Avian Medicine and Surgery·Jennilee MorrisonTomás Martín-Jiménez
Jun 30, 2019·Journal of Avian Medicine and Surgery·Ryan S BaileySathya K Chinnadurai
Sep 12, 2017·Journal of Avian Medicine and Surgery·David Sanchez-Migallon GuzmanJoanne R Paul-Murphy
Jun 24, 2017·Journal of Avian Medicine and Surgery·Noémie M SummaGuy Fitzgerald
Oct 4, 2019·Journal of Veterinary Pharmacology and Therapeutics·Irene SartiniMario Giorgi
Oct 18, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ibrahim Ozan TekeliKamil Uney
Dec 24, 2020·Journal of Avian Medicine and Surgery·Molly D HorganRebecca S Duerr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians
P K RobbinsArthur L Craigmill
Veterinary Therapeutics : Research in Applied Veterinary Medicine
Johann F CoetzeePortia S Allen
Journal of Veterinary Pharmacology and Therapeutics
H L HeebRobert P Hunter
American Journal of Veterinary Research
J E BirdG E Duke
© 2021 Meta ULC. All rights reserved