Pharmacokinetics of a single dose of teicoplanin in burn patients

The Journal of Antimicrobial Chemotherapy
J A SteerN Parkhouse

Abstract

Patients with severe burns are susceptible to infection with Gram-positive organisms including methicillin-resistant Staphylococcus aureus, and often require higher antibiotic dosages compared with other patients. This study examined the pharmacokinetics of a single iv dose of teicoplanin (12 mg/kg) in 15 adults and five children with severe burns. Adults were aged 21-82 years with a median total body surface area (TBSA) burn of 30% (range 15-60%). Children were aged 10 months-l0 years with median TBSA burn of 15% (10-30%). At 12 h, the median serum teicoplanin concentration was 12.8 mg/L (9.027.1 mg/L) in adults and 7.6 mg/L (6.6-l0.8 mg/L) in children, (P < 0.01); at 24 h, the corresponding values were 8.3 mg/L (4.6-l2.9 mg/L) and 5.2 mg/L (4.2-6.0 mg/L). Using a three-compartment model, the median terminal half life in adults was 114 h (47-278 h). Children fitted a two-compartment model with a terminal half-life of 38 h (2l-41 h). The median concentration of teicoplanin in fluid from the burn wound was 60% of the serum antibiotic concentration. A single iv dose of 12 mg/kg of teicoplanin was sufficient to produce therapeutic serum concentrations in burn patients for 24 h, but monitoring of antibiotic levels in serum may be a...Continue Reading

Citations

Jun 1, 1999·The Journal of Antimicrobial Chemotherapy·I F ChernA P Wilson
Oct 6, 2000·Clinical Pharmacokinetics·A P Wilson
Jan 7, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E S R Darley, A P MacGowan
Apr 7, 2011·Thérapie·Audrey BoulameryUNKNOWN Groupe Suivi Therapeutique Pharmacologique de la Societe Francaise de Pharmacologie et de Therapeutique
Oct 8, 1999·The Journal of Antimicrobial Chemotherapy·M J Weinbren
May 6, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Amanda N SteeleNam K Tran
Mar 12, 1999·British Journal of Clinical Pharmacology·E J BeggC J Kirkpatrick

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