PMID: 2111246Jan 1, 1990Paper

Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects

European Journal of Clinical Pharmacology
Meir BialerEmilio Perucca

Abstract

The pharmacokinetics of a single 400 mg oral dose of valnoctamide (VCD) has been investigated in seven healthy, adult, male volunteers. VCD was not biotransformed rapidly to its corresponding acid valnoctic acid (VCA), unlike its isomer valpromide (VPD). It had a mean residence time of 13.2 h and a terminal half-life of 9.3 h. Throughout the study, only low plasma levels of VCA could be detected. Thus, unlike VPD, which is a pro-drug of the corresponding acid, (valproic acid, VPA). VCD appears to act as a drug in its own right, and it does not undergo similar hydrolysis. The pharmacokinetic difference may account for the different pharmacological activities of the two isomers.

References

Oct 1, 1975·Clinical Pharmacology and Therapeutics·G R Wilkinson, D G Shand
Feb 8, 1985·Journal of Chromatography·M Bialer, B Hoch
Oct 1, 1988·Journal of Pharmaceutical Sciences·A Haj-Yehia, M Bialer
Jan 1, 1984·European Journal of Clinical Pharmacology·M BialerO Abramsky
Feb 1, 1982·Life Sciences·I M Lang, M F Tansy

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Citations

Feb 18, 1994·Pharmacy World & Science : PWS·M BialerS Hadad
Dec 23, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gaetano Zaccara, Dieter Schmidt
May 31, 2006·Congenital Anomalies·Akinobu Okada, Michio Fujiwara
Apr 20, 2006·Epilepsy Research·Michael A Rogawski
Jul 23, 2013·Clinical Biochemistry·Manuela G NeumanMeir Bialer
Sep 23, 2016·Virology·Sara OrnaghiAnthony N van den Pol
Sep 8, 2017·International Journal of Molecular Sciences·Alexei P KudinWolfram S Kunz
Oct 17, 2018·Birth Defects Research·Ying Linda LinBogdan J Wlodarczyk
Dec 2, 2020·Viruses·Sabina AndreuJosé Antonio López-Guerrero

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