Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique

PM & R : the Journal of Injury, Function, and Rehabilitation
Jilda N Vargus-AdamsAlexander A Vinks

Abstract

To evaluate the pharmacokinetics of amantadine in children with impaired consciousness from acquired brain injury. Randomized, double-blind, placebo-controlled, crossover study with sparse sampling for pharmacokinetics. Tertiary care pediatric hospital. Children, ages 6-18 years, with impaired consciousness 5-10 weeks after acquired brain injury. Subjects received amantadine for 3 weeks. Subjects were randomized to placebo or amantadine 4 mg/kg/day for 7 days followed by 6 mg/kg/day for 14 days. Crossover was after a 7-day washout period. The Coma/Near-Coma Scale and Coma Recovery Scale-Revised were done 3 times per week to evaluate arousal and consciousness. Plasma concentrations of amantadine were determined for pharmacokinetic parameter estimation and evaluation of the exposure-response relationship. Adverse events were monitored. Nine subjects met the final inclusion and exclusion criteria, 7 of whom agreed to participate. Five subjects completed both arms of the study. Amantadine total body clearance was 0.17 L/h/kg with a half-life of 13.9 hours. Higher exposure of amantadine (average concentration of amantadine during 6 mg/kg/day > 1.5 mg/L) may be associated with better recovery of consciousness. Amantadine was well-tol...Continue Reading

References

Dec 1, 1979·Clinical Pharmacology and Therapeutics·F Y AokiR I Ogilvie
Apr 16, 1985·European Journal of Pharmacology·G GianutsosJ P Dunn
Jan 1, 1988·Clinical Pharmacokinetics·F Y Aoki, D S Sitar
Feb 1, 1985·Clinical Pharmacology and Therapeutics·F Y Aoki, D S Sitar
Dec 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·D Z D'Argenio
Jul 8, 1998·Brain Injury : [BI]·R D ZafonteN R Mann
Jul 20, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·R F SuckowT B Cooper
Dec 31, 2004·American Journal of Physical Medicine & Rehabilitation·Liza B GreenEdward A Hurvitz
Sep 29, 2006·Journal of Child Neurology·Peter D PatrickMark R Conaway
Aug 31, 2007·Brain Injury : [BI]·Sharon E Williams
May 1, 2009·American Journal of Physical Medicine & Rehabilitation·Mary A McMahonJudy Bean

❮ Previous
Next ❯

Citations

Dec 18, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Diane MortimerMichelle A Potts
Feb 19, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Stacy J Suskauer, Melissa K Trovato
Mar 25, 2016·Fundamental & Clinical Pharmacology·Jann-Inn TzengChing-Hsia Hung
Feb 25, 2021·Journal of Neural Transmission·Wojciech DanyszPeter Riederer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

© 2021 Meta ULC. All rights reserved