PMID: 2112643May 1, 1990Paper

Pharmacokinetics of ampicillin during parenteral nutrition

JPEN. Journal of Parenteral and Enteral Nutrition
W W KooB Marriage

Abstract

Seven healthy volunteers (four males, 20-28 years) were studied to determine the effect of parenteral nutrition (PN) on ampicillin clearance. Each volunteer received intravenous infusions of 1 liter of PN (3.75% amino acid and 10% dextrose) alternating with 1 liter of 10% dextrose (containing all additives as PN except for calcium and phosphorus); and a meal containing similar fluid volume, caloric, protein, and sodium content as the PN solution. Ampicillin (250 mg) was given intravenously 2 hr after commencement of each intravenous solution and 4 hr after the meal. During PN infusion, the mean (+/- SE) glomerular filtration rate (GFR) as indicated by creatinine clearance was 125 +/- 18 ml/min; ampicillin pharmacokinetic data included area under the serum ampicillin concentration-time curve of 899 +/- 118 micrograms min/ml, terminal elimination half life of 37 +/- 4.3 min, volume of distribution at steady state of 11.9 +/- 1.6 liter, total body clearance of 4.7 +/- 0.6 ml/min/kg, renal clearance of 3.8 +/- 0.5 ml/min/kg, and 82 +/- 6.7% of the ampicillin administered was excreted in urine over 10 hr. The results were not significantly altered by different nutrient regimens or the order of infusion of intravenous solutions. We c...Continue Reading

References

Jan 1, 1989·Journal of Clinical Pharmacology·T M KittE Tsalikian
May 1, 1987·The Journal of Pediatrics·B H BrouhardL B Travis
Nov 1, 1986·Reviews of Infectious Diseases·G Foulds
Jun 1, 1988·Clinical Pharmacokinetics·K E Anderson
Sep 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·D R Antonow, C J McClain
Jan 20, 1983·The New England Journal of Medicine·H GrafR Prager
Aug 1, 1983·The American Journal of Clinical Nutrition·J M BengoaI H Rosenberg
Nov 1, 1983·Journal of Pediatric Gastroenterology and Nutrition·P S VenkataramanR C Tsang
Jun 1, 1984·Anesthesiology·E J PantuckA H Conney
Dec 1, 1983·The American Journal of Medicine·J P BoschS Glabman

❮ Previous
Next ❯

Citations

Jun 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David K A BarnesMorton Barlaz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Clinical Pharmacology
M F O'HareD G McDevitt
Clinical Pharmacology and Therapeutics
D R StanskiE Lowenstein
© 2021 Meta ULC. All rights reserved