Pharmacokinetics of azithromycin in trachoma patients: serum and tear levels

Ophthalmology
Z A KarciogluW S Ahmed

Abstract

To determine the effectiveness of single-dose oral azithromycin in the treatment of Chlamydia trachomatis through monitoring of tear and serum levels. Nonrandomized, clinical trial. Fourteen school-age children with active trachoma (one failed to complete the study). A single dose of azithromycin (20 mg/kg) was administered orally to 14 patients, and tear and serum levels were determined with high-performance liquid chromatography at 12, 24, 48, 72, 96, 120, and 144 hours after administration. Azithromycin levels in tears and serum. Peak levels of 1.53 microg/ml (standard deviation [SD] +/- 0.94) and 0.15 microg/ml (SD +/- 0.04) were obtained at 12 hours in both tears and serum, gradually decreasing over 144 hours. All patients were disease-free by 6 months. Levels of azithromycin in patients with trachoma were found to be within minimum inhibitory concentration range for Chlamydia trachomatis (0.03-0.25 microg/ml) throughout the monitored period of 6 days.

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Citations

Nov 1, 2003·The Lancet Infectious Diseases·Jeffrey W MecaskeyJoseph A Cook
Jun 6, 2009·Drugs·Anu A MathewHugh R Taylor
Mar 16, 2001·Expert Opinion on Pharmacotherapy·J M Duran, G W Amsden
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Jan 31, 2019·Expert Review of Anti-infective Therapy·Meraf A Wolle, Sheila K West
Dec 17, 2009·Tropical Medicine & International Health : TM & IH·C MpyetC Ogoshi

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