PMID: 7028947Oct 1, 1981Paper

Pharmacokinetics of captopril in dogs and monkeys

Journal of Pharmaceutical Sciences
S M SinghviB H Migdalof

Abstract

[14C]Captopril was given as a priming dose, followed by constant intravenous infusion for 4 or 6 hr, to three anesthetized dogs and three anesthetized monkeys. Blood, urine, and bile samples were collected during and after drug infusion. Pharmacokinetic evaluations were carried out exclusively on data obtained for unchanged captopril. The average total body clearance (ClT) and the renal clearance (ClR) of captopril, in milliliters per kilogram per hour, were 605 and 341 in the dog and 1135 and 944 in the monkey. The biliary clearance of captopril was negligible in both species. The greater difference between the ClR and ClT values in the dog compared to that in the monkey was the result of more extensive metabolism of captopril by the dog. Since almost all of the radioactive dose was recovered in urine in both species, captopril and its metabolites were almost exclusively eliminated by the kidneys. One primary reason that body and renal clearance values of captopril were much greater in the monkey than in the dog was that the net tubular secretion fo captopril was about three times greater in the monkey (82%) than in the dog (28%). The volume of distribution of captopril was higher in the monkey (3.6 liters/kg) than in the dog ...Continue Reading

Citations

Sep 15, 1985·Biochemical Pharmacology·O H DrummerB Jarrott
Jan 1, 1984·Drug Metabolism Reviews·B H MigdalofK J Kripalani
Jan 1, 1995·Current Medical Research and Opinion·M VerhoN Bender
Jul 1, 1996·Experimental Animals·H TsutsumiK Tokoi
Jan 1, 1986·Medicinal Research Reviews·O H Drummer, B Jarrott
May 1, 1990·DICP : the Annals of Pharmacotherapy·J J RaiaC R Lacy

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