Pharmacokinetics of cefaclor and cephalexin: dosage nomograms for impaired renal function.

Antimicrobial Agents and Chemotherapy
D A SpykerW K Bolton

Abstract

The pharmacokinetics of cefaclor and cephalexin were characterized in patients with creatinine clearances ranging from 0 to 147 ml/min. Each of 24 fasted subjects received a single 500-mg oral dose of cefaclor, and 13 of these subjects later received 500 mg of cephalexin. Serum and urine levels of the antibiotics were measured by bioassay. The serum half-lives were highly correlated with corrected creatinine clearance (cefaclor r = 0.92, cephalexin r = 0.94). Linear regression estimates of the half-life of cefaclor were 2.3 h in the anephric patient and 40 min in the patient with a corrected creatinine clearance of 100 ml/min. For cephalexin, corresponding half-lives were 15.4 h and 58 min. We present a dosage nomogram for calculating the appropriate adjustments to the loading dose based on patient weight and maintenence dose based on corrected creatinine clearance.

References

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Citations

Apr 1, 1991·Journal of Clinical Pharmacology·W C ShyuR H Barbhaiya
Jan 17, 2004·International Journal of Pharmaceutics·Joseph V TurnerDavid J Cutler
Jul 1, 1979·Antimicrobial Agents and Chemotherapy·H LodeP Koeppe
Dec 1, 1980·Antimicrobial Agents and Chemotherapy·W K BoltonM A Sande
Feb 1, 1982·Antimicrobial Agents and Chemotherapy·D A SpykerW K Bolton
Jan 1, 1979·Postgraduate Medical Journal·R B Kammer, L J Short
Feb 15, 2003·Journal of Pharmaceutical Sciences·Joseph V TurnerSnezana Agatonovic-Kustrin
Dec 1, 1987·Journal of Clinical Pharmacy and Therapeutics·N M NajibM E Abdulhameed
Jan 1, 1979·Infection·R B Kammer, L J Short
Jan 1, 1990·DICP : the Annals of Pharmacotherapy·G H Smith
May 1, 1981·The Annals of Otology, Rhinology & Laryngology. Supplement·R B Kammer
Jun 3, 2021·Pharmaceutics·Seung-Hyun JeongYong-Bok Lee

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