Pharmacokinetics of cefamandole and ampicillin in experimental meningitis.

Antimicrobial Agents and Chemotherapy
H N Beaty, E Walters

Abstract

The penetration of cefamandole and ampicillin into the cerebrospinal fluid of rabbits with and without pneumococcal meningitis was evaluated. In normal animals, a mean maximum concentration of 0.22 +/- 0.13 microgram of cefamandole per ml was measured in the spinal fluid after a dose of 150 mg/kg given intramuscularly; with 25 and 50 mg/kg doses, no antibiotic was detected in the cerebrospinal fluid. With ampicillin, in intramuscular doses of 200 and 300 mg/kg, the mean maximum concentrations encountered in the cerebrospinal fluid were 1.59 +/- 0.4 and 1.47 +/- 0.44 microgram/ml, respectively. Penetration of cefamandole, and to a lesser extent ampicillin, was increased after 24 h of experimental meningitis. With cefamandole, the concentration of drug in the cerebrospinal fluid exceeded the usual inhibitory concentration for Haemophilus influenzae only with the 150 mg/kg dose. After 48 h of meningitis, there was a trend toward higher levels of antibiotic in the cerebrospinal fluid, but the difference between animals infected 24 versus 48 h was not statistically significant. In animals with meningitis, serum concentrations after 150 mg of cefamandole per kg and both ampicillin doses studied were 32 to 38% lower than the serum lev...Continue Reading

References

Oct 1, 1975·The Journal of Infectious Diseases·C K McAllisterH N Beaty
May 1, 1978·The Journal of Infectious Diseases·E A SteinbergJ M Leedom
May 1, 1978·The Journal of Infectious Diseases·O M KorzeniowskiM A Sande
Jun 1, 1977·Antimicrobial Agents and Chemotherapy·E A SteinbergJ Wilkins
Sep 1, 1975·The Journal of Infectious Diseases·J E PenningtonJ D MacLowry
Jun 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·J M O'DonoghueH N Beaty
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