PMID: 3750783Jul 26, 1986Paper

Pharmacokinetics of cefotaxime in the dog

The Veterinary Record
V H GuerriniD W Bourne

Abstract

Each of five dogs was given cefotaxime at a dose rate of 50 mg/kg by intravenous, intramuscular and subcutaneous routes, in three separate treatments. Plasma concentration time profiles were characterised by a linear two-compartment model after the intravenous administration. After intravenous, intramuscular and subcutaneous injections the mean biological half-lives were 0.74, 0.83 and 1.71 hours, respectively. The apparent steady state volume of distribution was 0.48 litre/kg and body clearance after intravenous injection was approximately 0.63 litre/hour/kg. After intramuscular and subcutaneous injections peak plasma cefotaxime concentrations were 47 +/- 15 and 29.6 +/- 16 micrograms/ml at 0.5 and 0.8 hours, respectively. The average bioavailability of cefotaxime given by intramuscular injection was 86.5 per cent and for cefotaxime given subcutaneously it was approximately 100 per cent. After two hours, the cefotaxime plasma concentration remained higher after subcutaneous than after intramuscular administration.

Citations

Jun 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R N Jones
Oct 1, 1990·Antimicrobial Agents and Chemotherapy·J G ChristensonA Specian
Jul 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L HakimE J Triggs
Mar 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·K A Caprile
Dec 22, 2000·Research in Veterinary Science·K ABO EL-SOOUDA Goudah
Oct 1, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Mosab ArafatMomir Mikov
Apr 29, 2006·Journal of Veterinary Science·Suresh Kumar Sharma, Anil Kumar Srivastava
Nov 7, 2019·Tropical Animal Health and Production·Abdullah AltaybanMohammed Al-Nazawi
Feb 26, 2020·Journal of Veterinary Emergency and Critical Care·Christopher L Norkus, Iain Keir

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