PMID: 3770069Jan 1, 1986Paper

Pharmacokinetics of cimetidine after subchronic administration

European Journal of Clinical Pharmacology
T W ChinS J Soldin

Abstract

The influence of cimetidine on its own pharmacokinetics after subchronic administration was assessed in 8 healthy volunteers, aged 26-29 years. On control Day 1, each subject received cimetidine 300 mg i.v., and serum and urine samples were obtained. Each subject was initiated on cimetidine 600 mg b.i.d. orally for 2 weeks. There were 3 further study days repeated after 1 and 2 weeks of cimetidine dosing and 1 week after stopping cimetidine. There was no significant difference in the mean total body clearance of cimetidine among the 4 study days. Mean elimination t1/2 beta and V beta were similarly unchanged. However mean renal clearance (CLR) and fe were significantly increased following 2 weeks of drug dosing (CLR 5.41 ml X min-1 X kg-1; fe 0.61) compared to control (CLR 4.00 ml X min-1 X kg-1; fe 0.48). Although the non renal clearance was reduced from control values of 4.29 to 3.51 ml X min-1 X kg-1 following 2 weeks of dosing the difference was not significant. Dosage adjustment of cimetidine appears unnecessary after short-term dosing in the presence of normal renal function.

References

Dec 1, 1975·British Journal of Clinical Pharmacology·W L BurlandJ H Wyllie
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Jan 1, 1979·Therapeutic Drug Monitoring·S J SoldinW A Mahon
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Jan 1, 1984·British Journal of Clinical Pharmacology·G W MihalyW J Louis
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Jul 1, 1981·Clinical Pharmacokinetics·G BodemarA Walan
Apr 1, 1981·British Journal of Clinical Pharmacology·J WebsterR Griffiths

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Citations

Aug 4, 2009·Journal of Veterinary Pharmacology and Therapeutics·G Le TraonL J I Horspool

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