Pharmacokinetics of continuous intravenous infusion of methadone in the early post-burn period

Journal of Clinical Pharmacology
D D DensonP P Raj


The pharmacokinetics of methadone were studied in 14 patients with acute, severe burns and receiving an intravenous infusion of methadone to control their pain. Serum methadone concentrations were measured by gas chromatography on 5 mL arterial blood samples obtained at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0 and 24 hours after the start of infusion. Albumin and Alpha-1-Acid glycoprotein (AAG) were measured by radial immunodiffusion. Serum methadone concentration-time data were fit with the appropriate sum of exponentials equation using iterative nonlinear regression analysis. All serum methadone concentration-time data were best described by a monoexponential equation. Estimates of Vd (180 +/- 62 L) were not significantly different from those predicted for Vc from body weight using literature values (156 +/- 41). Estimates of Vd were, however, significantly lower than those predicted for Vz using literature values (282 +/- 74) (P less than 0.001). In addition, CL values (53.0 +/- 19.3 L/h) were significantly higher than those predicted from body weight using literature values (9.2 +/- 2.3 L/h) (P less than 0.001). These changes resulted in estimates of the elimination half-life for methadone of 2.6 +/- 1.1 h. Methadone protein bindi...Continue Reading


Dec 1, 1978·The Surgical Clinics of North America·P W Curreri, A Luterman
Dec 1, 1978·The Surgical Clinics of North America·B A Pruitt
Sep 1, 1989·The Journal of Burn Care & Rehabilitation·R ConcilusP P Raj
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Aug 1, 1997·Burns : Journal of the International Society for Burn Injuries·S K PalD Herndon
Apr 17, 2001·The Journal of Burn Care & Rehabilitation·T D LongT Jones
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May 6, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Amanda N SteeleNam K Tran
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