Pharmacokinetics of contrast agents targeted to the tumor vasculature in molecular magnetic resonance imaging

Contrast Media & Molecular Imaging
M OostendorpWalter H Backes

Abstract

Molecular magnetic resonance imaging (MRI) is increasingly used to investigate tumor angiogenic activity non-invasively. However, the pharmacokinetic behavior and tumor penetration of the often large contrast agent particles is thus far unknown. Here, pharmacokinetic analysis of cyclic asparagine-glycine-arginine (cNGR) labeled paramagnetic quantum dots (pQDs) was developed to quantify the contrast agent's homing efficacy to activated endothelial cells of angiogenic tumor vessels using dynamic contrast-enhanced (DCE) MRI. cNGR homes to CD13, an overexpressed aminopeptidase on angiogenic tumor endothelial cells. First, a two-compartment pharmacokinetic model, comprising the blood space and endothelial cell surface, was compared with a three-compartment model additionally including the extravascular-extracellular component. The resulting extravasation parameter was irrelevantly small and was therefore neglected. Next, the association constant K(a), the dissociation constant k(d) and the fractional plasma volume v(P) were determined from the time-series data using the two-compartment model. Magnitude and spatial distribution of the parameters were compared for cNGR-labeled and unlabeled pQDs. The tumor area with significant K(a) v...Continue Reading

References

Sep 1, 1992·International Journal of Peptide and Protein Research·M SchnölzerS B Kent
May 13, 1998·Journal of Clinical Pathology·T TsuzukiT Hayakawa
Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S A AndersonJ J Kotyk
Sep 25, 2001·Behavioural Neurology·Chris Rorden, Matthew Brett
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Anwar R Padhani
Oct 10, 2002·The Journal of Biological Chemistry·Giorgio ColomboAngelo Corti
Jun 5, 2003·Nature Medicine·Donald M McDonald, Peter L Choyke
Nov 30, 2004·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Samira GuccioneMark D Bednarski
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anne H SchmiederGregory M Lanza
Jun 2, 2005·Chemical Communications : Chem Comm·Anouk DirksenE W Meijer
Aug 30, 2005·International Journal of Radiation Oncology, Biology, Physics·Quido G de LussanetRegina G H Beets-Tan
Oct 6, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Willem J M MulderKlaas Nicolay
Apr 4, 2006·Chemical Communications : Chem Comm·Anouk DirksenTilman M Hackeng
Sep 23, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Alexandra BuehlerEbo D de Muinck
Jan 2, 2007·The Lancet Oncology·Mark A ZahraLi T Tan
Jun 25, 2008·Blood·Angelo CortiRenata Pasqualini
Aug 14, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne H SchmiederGregory M Lanza
Nov 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anne M NeubauerSamuel A Wickline
Jan 15, 2009·Cancer Research·Zdravka MedarovaAnna Moore
Mar 7, 2009·Accounts of Chemical Research·Luis M De Leon-RodriguezA Dean Sherry

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