PMID: 8470137Mar 1, 1993Paper

Pharmacokinetics of cytotoxin from Chinese cobra (Naja naja atra) venom

Toxicon : Official Journal of the International Society on Toxinology
M P GuoG F Liu

Abstract

The pharmacokinetics of cytotoxin from Chinese cobra (Naja naja atra) venom was studied in rabbits after i.v. and i.m. injection of 0.2 and 0.5 mg.kg-1, respectively. The plasma levels of the cytotoxin were analysed by a biotin-avidin enzyme-linked immunosorbent assay. The plasma concentration-time course after i.v. administration fitted a two-compartment open model. The half-life (mean +/- S.D.) of the alpha-phase was 5.8 +/- 0.6 min and that of the beta-phase 3.5 +/- 0.2 hr. Apparent volume of distribution was 1.7 +/- 0.3 litres.kg-1, and clearance was 5.6 +/- 1.4 ml.min-1. A rapid absorption was observed after i.m. injection with peak plasma level of 260 +/- 90 ng.ml-1 reached within 13.6 +/- 2.4 min. The absorption rate constant was 0.16 +/- 0.03 ml-1. The area under the plasma concentration-time curve was 33 +/- 15 micrograms.min.ml-1.

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Citations

May 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·M TanigawaH Mihara
Sep 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·M NakamuraT Kosugi
Mar 30, 2013·Toxicon : Official Journal of the International Society on Toxinology·Michelle Khai Khun YapShin Yee Fung
Oct 16, 2001·Toxicon : Official Journal of the International Society on Toxinology·H ZhaoZ Jiang
Mar 27, 2003·Toxicon : Official Journal of the International Society on Toxinology·Dong-Zong HungShoei-Yn Lin-Shiau
Mar 19, 1999·Toxicon : Official Journal of the International Society on Toxinology·Z E Selvanayagam, P Gopalakrishnakone
Jul 20, 2005·Clinical and Experimental Pharmacology & Physiology·Sheng-Huei YangShinne-Ren Lin
Feb 21, 2006·Clinical and Experimental Pharmacology & Physiology·Chia-Houng TsaiShinne-Ren Lin
May 29, 2008·Clinical and Experimental Pharmacology & Physiology·Ching-Ming ChienShinne-Ren Lin
Aug 8, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chih-Chuan LinChiung-Yao Tseng
Mar 13, 2010·Toxicon : Official Journal of the International Society on Toxinology·S KulawickramaG K Isbister
Feb 11, 2010·Toxicon : Official Journal of the International Society on Toxinology·Kuei-Li LinShinne-Ren Lin
Oct 13, 2009·Toxicon : Official Journal of the International Society on Toxinology·Sueli M MelloStephen Hyslop
Jul 16, 2008·Toxicon : Official Journal of the International Society on Toxinology·Marilene L RochaDemetrius A M Araujo
Jun 28, 2008·Toxicon : Official Journal of the International Society on Toxinology·A F Wahby, N M Ibrahim
Mar 21, 2007·Toxicon : Official Journal of the International Society on Toxinology·Sheng-Huei YangShinne-Ren Lin
Jun 9, 2004·Biochemical and Biophysical Research Communications·Ya-Ling LinLong-Sen Chang
Jun 19, 2008·Journal of Biochemical and Molecular Toxicology·Sheng-Huei YangShinne-Ren Lin
Mar 15, 2005·Life Sciences·Sheng-Huei YangShinne-Ren Lin
Jan 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Mohamed Naceur KrifiValérie Choumet
Jun 13, 2006·Toxicon : Official Journal of the International Society on Toxinology·Margaret A O'LearyBart J Currie
Aug 6, 2005·Toxicon : Official Journal of the International Society on Toxinology·Chia-Hui WangWen-guey Wu
Nov 11, 2003·The Journal of Pharmacy and Pharmacology·Liu XingShao Lan
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Dec 7, 2006·Molecular and Cellular Biochemistry·Sheng-Huei YangShinne-Ren Lin
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