Pharmacokinetics of ethylene glycol. II. Tissue distribution, dose-dependent elimination, and identification of urinary metabolites following single intravenous, peroral or percutaneous doses in female Sprague-Dawley rats and CD-1 mice

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
S W FrantzB Ballantyne

Abstract

1. [1,2]-14C-Ethylene glycol (EG) was given to female CD (Sprague-Dawley) rats and CD-1 mice in order to determine tissue distribution and metabolic fate after intravenous (iv), peroral (po), and percutaneous (pc) doses. Rats were given doses of 10 or 1000 mg/kg by each route, and additional pc doses of 400, 600 or 800 mg/kg. Mice were also given iv and po doses of 10 or 1000 mg/kg, and intermediate po doses of 100, 200 or 400 mg/kg. Mice were given po doses of 100 or 1000 mg/kg, and both species were given a 50% (w/w) aqueous po dose to simulate antifreeze exposure. 2. For both species, EG is very rapidly and almost completely adsorbed after po doses. Perorally administered EG doses produced similar dose-dependent relationships described in prior studies for the disposition and excretion of iv doses. 3. The tissue distribution of EG following either iv or po routes was essentially the same, with similar percentages recovered for each dose by both routes and for either species. 4. Cutaneously-applied EG was slowly and rather poorly adsorbed in both species, in comparison with po-dose administration, and urinalysis after undiluted po doses indicated that EG probably penetrates rat skin in the parent form. There was an absence in...Continue Reading

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Citations

May 12, 2004·Reproductive Toxicology·UNKNOWN Center for the Evaluation of Risks to Human Reproduction
Nov 8, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S KlugR Jäckh
May 24, 2008·International Journal of Cosmetic Science·L H Couch, P C Howard
Jan 27, 2004·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E D BoothW P Watson
Nov 26, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Edward W CarneyNigel Moore
Jun 28, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bryan Ballantyne, William M Snellings
May 8, 2010·International Journal of Toxicology·Shakil A SaghirWilliam M Snellings
Feb 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·R A CorleyK D Thrall
Apr 28, 2005·American Journal of Physiology. Renal Physiology·Mike L GreenRobert W Freel
Feb 27, 2009·American Journal of Physiology. Renal Physiology·Yan Li, Kenneth E McMartin

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