PMID: 697083Oct 1, 1978Paper

Pharmacokinetics of etomidate, a new intravenous anesthetic

Anesthesiology
M J Van HammeJ J Ambre

Abstract

Etomidate sulfate, 0.3 mg/kg, was administered intravenously to eight patients and venous blood samples were drawn at intervals for the subsequent 10 hours. Plasma etomidate was determined by mass fragmentography. Plasma concentrations were fitted to a triexponential equation consistent with a three-compartment open pharmacokinetic model. Mean (+/-SD) variables were: initial t1/2, 2.6 +/- 1.3 min; intermediate t1/2, 28.7 +/- 14.0 min; apparent elimination t1/2, 4.6 +/- 2.6 hours; volume of the central compartment, 23.2 +/- 11.41; total apparent volume of distribution, 4.5 +/- 2.21/kg; fraction of drug in the central compartment, 7 per cent; total plasma clearance, 860 +/- 230 ml/min. Total blood clearance was estimated to be 754 ml/min and hepatic clearance, 739 ml/min. The large apparent volume of distribution indicates considerable tissue uptake. The hepatic clearance, being about 50 per cent of hepatic blood flow, indicates that changes in hepatic blood flow or hepatic metabolism will have only moderate effects on etomidate disposition.

Citations

Jun 1, 1989·Computers and Biomedical Research, an International Journal·P J Lago
Feb 1, 1992·Computers and Biomedical Research, an International Journal·P J Lago
Jul 2, 1983·Lancet
Mar 29, 2001·Journal of Pharmaceutical and Biomedical Analysis·M P McIntosh, R A Rajewski
Mar 1, 1997·The Journal of Emergency Medicine·J M Bergen, D C Smith
Jan 25, 2000·The Journal of Emergency Medicine·D C SmithR Kirschner
Sep 29, 1999·European Journal of Anaesthesiology·W KrumholzG Hempelmann
Mar 23, 2002·International Anesthesiology Clinics·Samir Patel
Feb 1, 1991·Acta Anaesthesiologica Scandinavica·P DuvaldestinR Farinotti
Oct 11, 2012·Emergency Medicine International·Oliver Flower, Simon Hellings
Aug 1, 1996·Anesthesia and Analgesia·J P Mulier, H Van Aken
May 19, 1998·Anesthesia and Analgesia·J ZhangJ B Streisand
Apr 23, 2003·Anesthesia and Analgesia·Ken B JohnsonScott W McJames
Aug 30, 2012·European Journal of Endocrinology·Lip Min SohWilliam M Drake
Feb 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J L C M DorneA G Renwick
Jan 1, 1989·Intensive Care Medicine·P YeomanS Durham
May 1, 1995·Disease-a-month : DM·R C BoneM Guerrero
May 10, 1985·Journal of Chromatography·H Heusler
Jan 14, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Susan C Urwin, David K Menon
Sep 7, 2004·Journal of Pharmaceutical Sciences·Michelle P McIntoshRoger A Rajewski
Nov 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·C S Gallagher, J R Hann
Mar 13, 2012·Veterinary Anaesthesia and Analgesia·Juan Morgaz RodríguezMaría M Granados Machuca
May 26, 2010·Journal of Clinical Pharmacology·Kotaro KanedaTae-Hyung Han
Mar 5, 2014·Acta Anaesthesiologica Scandinavica·G ErdoesB Eberle
Jan 1, 1989·Journal of Clinical Anesthesia·M A Skues, C Prys-Roberts
Aug 1, 1988·Anaesthesia·M C DiagoJ J Lopez-Cordovilla
Mar 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·J MonbaliuJ Heykants
Aug 1, 1983·Anaesthesia·F CarliM M Clark

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.