PMID: 42420Oct 1, 1979

Pharmacokinetics of fazadinium in patients with renal failure

British Journal of Anaesthesia
P DuvaldestinJ M Desmonts


The serum concentrations of fazadinium and its metabolites were measured in 14 surgical patients with end-stage renal failure and in 11 patients free from kidney disease undergoing abdominal surgery. A two-compartment open model was used in the pharmacokinetic analysis of the data. The elimination half-life (T 1/2 beta) was prolonged by 60% in patients with renal failure (from 85 to 140 min) and corresponded to a 30% decrease of the plasma clearance. The plasma concentration of the metabolites never exceeded 7% of the unchanged fazadinium. These results suggest that the duration of action will be less prolonged for fazadinium than for other non-depolarizing neuromuscular blocking drugs in patients with renal failure. A supplementary biliary pathway appears to be a possible explanation for the rapid elimination of fazadinium, even in patients with renal failure.


Jan 1, 1981·European Journal of Clinical Pharmacology·D R BevanR L Smith
Mar 7, 2002·British Journal of Anaesthesia·C Lee
Apr 1, 1984·Acta Anaesthesiologica Scandinavica·M P RainaldiS Boschi
Dec 1, 1981·The Australian and New Zealand Journal of Surgery·J Gomez-ArnauF Avello
Nov 1, 1983·Anaesthesia and Intensive Care·P J Maddern

Related Concepts

Kidney Failure, Chronic
Pyridinium Compounds
Operative Surgical Procedures

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