PMID: 8583538Aug 1, 1995Paper

Pharmacokinetics of flunixin and its effect on prostaglandin F2 alpha metabolite concentrations after oral and intravenous administration in heifers

Journal of Veterinary Pharmacology and Therapeutics
K Odensvik

Abstract

Flunixin meglumine (FM) was administered either orally as granules or intravenously to six heifers in a two period crossover study. Single doses of 2.2 mg/kg body weight were used. Pharmacokinetic variables were calculated using statistical moment methods. The effect exerted by flunixin was measured as changes in the basal plasma concentration of the main metabolite of prostaglandin (PG) F2 alpha. After oral FM the arithmetic means of pharmacokinetic variables were: MRT = 12.7 h; MAT = 6.3 h; Cmax = 0.9 microgram/mL; tmax = 3.5 h. The bioavailability was 60% and the mean half-life (harmonic mean) was 6.2 h. Oral administration of FM inhibited as effectively as intravenous administration the prostaglandin biosynthesis. The concentration of the PG metabolite decreased almost as rapidly as after intravenous administration. The duration of the effect was prolonged and the PG metabolite concentration was significantly lower between 10 and 30 h after oral than after intravenous administration. The results indicate that oral dosing of flunixin, in the form of granules, can be an alternative to intravenous administration for therapeutic use in cattle.

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Citations

Mar 24, 2004·Theriogenology·Kyoung-Jin YoonLawrence E Evans
Jun 6, 1998·Animal Reproduction Science·K OdensvikH Kindahl
Jan 14, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·K Baert, P De Backer
Nov 7, 2001·Journal of Veterinary Pharmacology and Therapeutics·C B NavarreD G Pugh
Dec 18, 2002·Journal of Veterinary Pharmacology and Therapeutics·K Baert, P De Backer
Feb 27, 2013·The Veterinary Clinics of North America. Food Animal Practice·Geof Smith
Feb 27, 2013·The Veterinary Clinics of North America. Food Animal Practice·Johann F Coetzee
Jan 9, 2001·The Veterinary Journal·B L CoomberP A Gentry
Dec 18, 2014·Journal of the American Veterinary Medical Association·Lindsey W KissellGeof W Smith
Aug 2, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Teresa L LeavensJim E Riviere
Nov 3, 2016·Journal of Veterinary Pharmacology and Therapeutics·M D KleinhenzJ F Coetzee
May 27, 2016·American Journal of Veterinary Research·Lindsey W KissellGeof W Smith
Jan 24, 2009·Journal of Dairy Science·A HeinrichS T Millman
Feb 21, 2018·Journal of Veterinary Pharmacology and Therapeutics·M D KleinhenzJ F Coetzee
Mar 4, 2008·Journal of the American Veterinary Medical Association·Geof W SmithJim E Riviere
Jul 30, 2019·Journal of Veterinary Pharmacology and Therapeutics·Emily J ReppertJohann F Coetzee
Sep 22, 2010·Australian Veterinary Journal·J W FinnieM M Williamson
Mar 21, 2007·Journal of Animal Science·M L MerrillT W Geary
Jan 7, 2017·Journal of the American Veterinary Medical Association·Pritam K SidhuJim E Riviere
May 16, 2019·Journal of Veterinary Pharmacology and Therapeutics·Tim MorrisSteven Karamatic
Nov 26, 2009·Journal of Animal Science·T W GearyR C Waterman
Jan 23, 2021·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Ursula BechertSumeia Mohammed
Jan 15, 2019·Research in Veterinary Science·Nancy W ShappellKathryn A Bartholomay

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