PMID: 9549638Apr 29, 1998Paper

Pharmacokinetics of fosinoprilat in Chinese and whites after intravenous administration

Journal of Clinical Pharmacology
O Y HuK M Chu

Abstract

The pharmacokinetics of fosinoprilat was studied in 12 healthy Chinese men after a 7.5 mg intravenous dose of fosinoprilat. The data were compared with those from an earlier study using the same protocol in nine healthy white men. Blood and urine samples were obtained before and at various time intervals after fosinoprilat administration up to 24 hours and 48 hours, respectively. Pharmacokinetic parameters were calculated by fitting the plasma or serum concentrations to a three-compartment model. The total clearance (Clt), renal clearance (ClT), and nonrenal clearance (ClNR) were significantly lower in Chinese (16.29 +/- 6.92, 6.85 +/- 2.97, and 9.44 +/- 5.08 mL.hr-1.kg-1) than those obtained in whites (29.88 +/- 6.36, 13.55 +/- 3.45, and 16.33 +/- 5.07 mL.hr-1.kg-1). The Chinese subjects had a significantly lower volume of distribution (Vc [volume of distribution of central compartment] and Vdss [volume of distribution at steady state]) (29.38 +/- 21.12 and 73.67 +/- 40.20 mL/kg) than white men (58.14 +/- 15.01 and 152.49 +/- 24.89 mL/kg). The Chinese men also had a shorter elimination half-life than whites, although not statistically significant. The respective half-lives in Chinese and whites were 5.51 +/- 1.53 and 8.24 +/- ...Continue Reading

References

Apr 1, 1991·Clinical Pharmacology and Therapeutics·K K HuiN Yanagawa
May 1, 1991·Clinical Pharmacokinetics·A J Wood, H H Zhou
Jul 1, 1990·Clinical Pharmacology and Therapeutics·H H ZhouG R Wilkinson
Jan 1, 1988·British Journal of Clinical Pharmacology·S M SinghviM Frantz
Sep 1, 1982·Clinical Pharmacokinetics·W Kalow
Jan 1, 1994·Clinical Pharmacokinetics·F J Gonzalez, J R Idle
Nov 1, 1993·Clinical Pharmacology and Therapeutics·H H ZhouA J Wood
Jul 1, 1993·Clinical Pharmacology and Therapeutics·E J Lee, W Kalow
Jan 1, 1993·European Journal of Clinical Pharmacology·B KlemetsdalJ Aarbakke
Sep 21, 2001·Journal of Clinical Pharmacology·P Y DingW C Liao
Sep 8, 2010·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·J AhnK-Y Jahng

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Citations

Feb 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J L C M DorneA G Renwick
Sep 3, 2004·Journal of Clinical Pharmacology·Kiman KimHartmut Derendorf
Nov 13, 2012·Annual Review of Pharmacology and Toxicology·Kari M MorrisseyKathleen M Giacomini

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