PMID: 3383966Apr 1, 1988Paper

Pharmacokinetics of free and total platinum species after rapid and prolonged infusions of aqua (1,1-bis(aminomethyl)cyclohexane) sulfatoplatinum (II) (spiroplatin) during a phase I trial

European Journal of Cancer & Clinical Oncology
W J van der VijghH M Pinedo

Abstract

The pharmacokinetics of the second generation platinum complex aqua(1,1-bis-(aminomethyl)cyclohexane)sulphatoplatinum(II) (spiroplatin, TNO-6) were studied during a phase I evaluation. Thirty patients received 49 cycles of spiroplatin by short term (less than or equal to 10-min), 1-, 3- or 6-h infusion. Dosages given ranged from 5 to 40 mg/m2. Platinum determinations were performed by atomic absorption spectrometry. Up to 5 days after administration platinum concentrations in plasma decayed triexponentially. Pharmacokinetic parameters of total platinum in plasma after short-term and prolonged infusion were similar in terms of terminal half-life (3.7 +/- 1.1 and 3.6 +/- 0.5 days), AUC/dose (548 +/- 106 and 616 +/- 278 min.m2/l), volume of distribution (20 +/- 6 and 27 +/- 81) and total body clearance (2.9 +/- 1.0 and 3.4 +/- 1.8 ml/min), whereas peak plasma concentrations were two times lower after prolonged infusion. The cumulative urinary platinum excretion after short-term infusion was 20 +/- 6%, 30 +/- 6% and 47 +/- 7% of the administered dose after 6, 24 and 120 h, respectively. These values are comparable to those after administration of cisplatin. The half-life of ultrafilterable platinum was 4.4 +/- 0.7 min. The curves o...Continue Reading

References

Jan 1, 1986·Cancer Chemotherapy and Pharmacology·W J van der Vijgh, I Klein
Apr 1, 1985·European Journal of Cancer & Clinical Oncology·J J OffermanG K van der Hem
Oct 1, 1985·Cancer·J J OffermanE G de Vries
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Citations

Jan 1, 1992·British Journal of Clinical Pharmacology·J D HoldingP M Stell
Jan 1, 1990·Journal of Pharmaceutical and Biomedical Analysis·W A De WaalJ C Kraak
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B C TanisH M Pinedo
Mar 6, 2007·Critical Reviews in Oncology/hematology·David J Stewart
Feb 21, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Haytham Al-MahalawyBadr Al-Jandan
Nov 17, 2010·International Journal of Pharmaceutics·Agnieszka KowalczukNeli Koseva
Jun 14, 2008·Cell Biology International·Pierre-Emmanuel PuigBruno Chauffert
Feb 11, 2016·World Journal of Clinical Oncology·Deepak KilariEric S Kim
Aug 8, 2009·Veterinary Dermatology·Samantha L CrothersVerena K Affolter

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