PMID: 639832Mar 17, 1978Paper

Pharmacokinetics of furosemide in anephric patients and in normal subjects

European Journal of Clinical Pharmacology
F AndreasenE Mikkelsen

Abstract

The pharmacokinetics of furosemide 40 mg i.v. were compared in 7 anephric patients and in 7 normal subjects. The average serum clearance was 66 ml/min in the patients and 219 ml/min in the normal subjects, and the corresponding weight corrected clearances were 1.33 ml/min . kg and 2.96 ml/min . kg. Binding to serum proteins was significantly decreased in the anephric subjects, in whom a significant negative correlation was found between the percentage binding and the volume of distribution VDSS. In the patients, but not in the normal subjects, there was a significant positive correlation between VDSS and serum clearance. Both in normal and anephric individuals 4-chlor-5-sulphamoyl-anthranilic-acid (CSA) was found, but there was no evidence of special accumulation either of CSA or anthranilic acid in the anephric patients. In the patients the initial increase in serum concentration of sodium and protein followed by a more conspicuous decrease were more pronounced, but none of the changes were statistically significant.

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Citations

Jan 1, 1991·European Journal of Clinical Pharmacology·J PrandotaJ T Wilson
Dec 1, 1978·European Journal of Clinical Pharmacology·F AndreasenE Mikkelsen
Jul 1, 1980·European Journal of Clinical Pharmacology·J V ArandaB I Sasyniuk
Jan 1, 1982·European Journal of Clinical Pharmacology·E RivaA Bettinelli
Oct 1, 1986·Archives of Gerontology and Geriatrics·W MühlbergE Neubig
Nov 1, 1989·Archives of Gerontology and Geriatrics·W Mühlberg
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·E DoyleJ N Miller
Sep 10, 1998·Journal of Veterinary Pharmacology and Therapeutics·T M DykeK W Hinchcliff
Aug 1, 1984·Kidney International·D C BraterS Anderson
Jan 24, 1986·The American Journal of Cardiology·D C Brater
May 1, 1980·British Journal of Clinical Pharmacology·J PerezR I Ogilvie
Jun 1, 1982·European Journal of Clinical Investigation·F AndreasenO L Pedersen
Nov 1, 1982·The Journal of Pediatrics·J V ArandaD S Sitar
Oct 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·P ChennavasinD C Brater
Feb 1, 1979·Journal of Pharmacokinetics and Biopharmaceutics·L Z Benet
Feb 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·M Hammarlund-Udenaes, L Z Benet
Dec 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·D E Smith, L Z Benet
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Sep 1, 1980·Acta Pharmacologica Et Toxicologica·F Andreasen, S Husted
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Jan 1, 1984·Acta Pharmacologica Et Toxicologica·B Beermann
Sep 1, 1981·Acta Pharmacologica Et Toxicologica·F AndreasenC E Mogensen

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