Pharmacokinetics of furosemide in thoroughbred horses subjected to supramaximal treadmill exercise with and without controlled access to water

BMC Veterinary Research
N F VillarinoW M Bayly

Abstract

The primary objective of this study was to assess the disposition of furosemide in Thoroughbred horses treated intravenously with 1 mg/kg of furosemide 4 and 24 h before supramaximal treadmill exercise without and with controlled access to water, respectively. Another objective was to determine whether furosemide was detectable in the plasma of horses after exposure to supramaximal treadmill exercise. Thoroughbred horses (n = 4-6) were administered single intravenous doses of 1 mg/kg of furosemide at 4 and 24 h before supramaximal exercise on a high-speed treadmill, with controlled and free access to water, respectively. Plasma furosemide concentrations were determined using liquid chromatography. Furosemide was detected in all the horses, regardless of whether they were treated 24 h or 4 h before excersice. In both treatment sequence groups of 2 horses, the concentration time profiles of furosemide during the first 4 h after its administration were relatively similar. The average maximum observed concentrations, AUC0-1.5h, and AUC0-3h, of both groups of horses were not different (p > 0.05). There were no significant differences in systemic clearance based on the geometric mean (95% confidence interval) (409 (347-482) mL/h/kg) ...Continue Reading

References

Oct 1, 1976·British Journal of Sports Medicine·G Jaggard
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Apr 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·T M DykeW W Muir
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Jul 2, 2009·Journal of the American Veterinary Medical Association·Kenneth W HinchcliffAlan J Guthrie
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Oct 24, 2017·Journal of Veterinary Pharmacology and Therapeutics·H K KnychJ H Jones

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Citations

Jan 14, 2021·Drug Testing and Analysis·Fernando MoreiraMaria de Lourdes Bastos
Dec 15, 2020·Journal of Veterinary Pharmacology and Therapeutics·Duygu Durna CorumKamil Uney
Aug 25, 2021·Journal of Veterinary Pharmacology and Therapeutics·Gul CetinKamil Uney

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