Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in pigs

Research in Veterinary Science
H WynsS Croubels

Abstract

The aim of this study was to investigate the pharmacokinetic properties of gamithromycin in pigs after an intravenous (i.v.) or subcutaneous (s.c.) bolus injection of 6 mg/kg body weight. The plasma concentrations of gamithromycin were determined using a validated high-performance liquid chromatography-tandem mass spectrometry method, and the pharmacokinetics were noncompartmentally analysed. Following i.v. administration, the mean area under the plasma concentration-time curve extrapolated to infinity (AUCinf) and the mean elimination half-life (t1/2λz) were 3.67 ± 0.75 μg.h/mL and 16.03 h, respectively. The volume of distribution at steady state (Vss) and the plasma clearance were 31.03 ± 6.68 L/kg and 1.69 ± 0.33 L/h.kg, respectively. The mean residence time (MRTinf) was 18.84 ± 4.94 h. Gamithromycin administered subcutaneously to pigs demonstrated a rapid and complete absorption, with a mean maximal plasma concentration (Cmax) of 0.41 ± 0.090 μg/ml at 0.63 ± 0.21 h and a high absolute bioavailability of 118%. None of the reported pharmacokinetic variables significantly differed between both administration routes.

References

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Citations

Nov 9, 2015·Veterinary Immunology and Immunopathology·Heidi WynsSiska Croubels
May 14, 2016·Avian Pathology : Journal of the W.V.P.A·Anneleen WatteynSiska Croubels
Mar 21, 2017·Journal of Veterinary Pharmacology and Therapeutics·S BerlinW Siegmund
May 18, 2017·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Ilka Ute Emmerich
Dec 19, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Vasileios PapatsirosGeorgios Christodoulopoulos
Oct 16, 2020·Veterinary Medicine and Science·Dietmar HamelSteffen Rehbein

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