PMID: 1202109Dec 1, 1975Paper

Pharmacokinetics of gentamicin in children and adults

The Journal of Infectious Diseases
G R SiberD H Smith

Abstract

Peak concentrations and half-life of gentamicin in serum were measured after 140 intravenous and 13 intramuscular doses in 52 children and 17 adults with normal levels of creatinine in serum. Marked interpatient variation in peak concentrations and half-life of gentamicin was observed, but individual patients tended to have similar values on repeated determinations. Age markedly affected the peak concentrations: a 1-mg/kg dose produced mean peak concentrations of 1.58, 2.03, and 2.81 mug/ml in the one-half to five, five to 10, and greater than 10 year age groups, respectively. This age-related change in dose response was diminished when the dose was calculated on the basis of body surface area. Patients in whom gentamicin had a short half-life, patients with fever, and adults with a high extracellular fluid volume had low peak concentrations. The mean half-life after intravenous administration was 75 min (range, 26-230 min). The mean half-life was 29 min longer after intramuscular dosage (p less than 0.01). A low rate of creatinine clearance was associated with a long half-life; fever and anemia were associated with a short half-life. The dosage of gentamicin necessary to produce mean peak serum concentrations between 4 mug/ml ...Continue Reading

Citations

Jan 1, 1990·European Journal of Clinical Pharmacology·Y M el-Sayed, S I Islam
Jan 1, 1989·Veterinary Research Communications·S K Garg, B D Garg
Jan 1, 1982·European Journal of Clinical Pharmacology·M E BravoA N Jahn
Jan 1, 1983·European Journal of Clinical Pharmacology·L A BauerD A Simonowitz
Mar 1, 1991·Indian Journal of Pediatrics·M ShahidullahA Rashid
Jul 3, 2009·Veterinary Research Communications·Santosh KumarBirendra K Roy
Mar 27, 2013·Paediatric Drugs·Amanda K Sullins, Susan M Abdel-Rahman
Dec 1, 1980·Computer Programs in Biomedicine·T J Sullivan, D J Wunderley
Aug 7, 1998·Journal of Pediatric Surgery·K D BassG M Haase
Feb 1, 1982·The Journal of Pediatrics·H B KellyS Murphy
Oct 24, 1998·Journal of Clinical Pharmacy and Therapeutics·S RomanoJ M Lanao
Sep 19, 2003·The New England Journal of Medicine·Gregory L KearnsRalph E Kauffman
Mar 6, 2012·British Journal of Anaesthesia·B S MohammedJ S McLay
Mar 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·S A Brown, J E Riviere
Jun 1, 1980·Australian Paediatric Journal·A M Finn, P J Pemberton
Jul 1, 1976·Antimicrobial Agents and Chemotherapy·B R MeyersB Ribner
Mar 1, 1982·Antimicrobial Agents and Chemotherapy·D E ZaskeR G Strate
Mar 1, 1985·Antimicrobial Agents and Chemotherapy·C H KingJ J Ellner
Jul 1, 1988·Antimicrobial Agents and Chemotherapy·A L SmithV P Syriopoulou
Jun 1, 1992·Antimicrobial Agents and Chemotherapy·J M EntenzaM P Glauser
Oct 17, 2006·Clinical Microbiology Reviews·Joseph MeletiadisThomas J Walsh
Feb 1, 1980·Archives of Disease in Childhood·G W Rylance, T A Moreland
Jan 1, 1992·Archives of Disease in Childhood·H SkopnikG Heimann
May 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Zaccaria RicciPaolo Pietropaoli
Nov 13, 2013·Paediatric Drugs·Chris StockmannCatherine M T Sherwin
Jan 1, 1979·Scandinavian Journal of Infectious Diseases. Supplementum·G Kahlmeter
Jan 1, 1992·Mayo Clinic Proceedings·K H Rhodes, N K Henry
Oct 6, 2012·Pediatric Clinics of North America·Ryan S FunkSusan M Abdel-Rahman
Aug 30, 2008·Pediatric Neurology·Patricio S EspinosaRobert J Baumann
Jul 1, 1978·The Journal of Pediatrics·W E EvansS Chaudhary
Aug 19, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Anil Dhawan
Dec 1, 1978·The American Journal of Medicine·R G Strauss
Jul 1, 1989·British Journal of Clinical Pharmacology·C P Denaro, P J Ravenscroft
Oct 1, 1989·British Journal of Clinical Pharmacology·B J ZarowitzE L Peterson
Oct 1, 1987·Journal of Clinical Pharmacy and Therapeutics·A Mathews, G R Bailie
Jun 1, 1985·Journal of Clinical and Hospital Pharmacy·H Chrystyn, J M Alexander
Jul 1, 1981·Journal of Clinical Pharmacology·I SketrisR J Cipolle
May 1, 1981·British Journal of Clinical Pharmacology·T H HallynckL Dettli
Aug 1, 1977·The Journal of Pediatrics·B VogelsteinP S Lietman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.