PMID: 8585090Sep 1, 1995Paper

Pharmacokinetics of habutobin in rabbits

Toxicon : Official Journal of the International Society on Toxinology
M NakamuraT Kosugi

Abstract

Following the administration of habutobin, the fibrinogen level in the circulating blood of the rabbits decreased. These results showed that the activity of habutobin was retained in vivo. The plasma level of habutobin was determined by a ELISA-double sandwich method. The pharmacokinetics of habutobin from Trimeresurus flavoviridis venom was studied in rabbits following i.v. administration of 50 micrograms kg-1 of habutobin. The time course of the plasma concentration of habutobin fitted a two-compartment open model. The half-life of the distribution phase was 4.43 +/- 1.28 min and that of the elimination phase was 50.42 +/- 7.89 min. The area under the plasma concentration-time curve (AUC) was 38.69 +/- 6.68 micrograms min ml-1. The total body clearance was 3.82 +/- 1.08 ml min-1. When the steady state was reached, the concentration ratio of habutobin in the tissue (Ct) to that in the plasma (Cc), Ct:Cc was 0.47:1. These findings suggest that relatively little habutobin tended to remain in the tissue.

References

Oct 12, 1978·Nature·B BlombäckL Therkildsen
Oct 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·M NakamuraT Kosugi
Jan 1, 1986·Annals of the New York Academy of Sciences·P C Harpel, J W Fenton
Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology· Maung-Maung-Thwin Thein-Than
Nov 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·K KinjohT Kosugi
Oct 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·M NakamuraT Kosugi
Mar 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·M P GuoG F Liu

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Citations

Mar 30, 2013·Toxicon : Official Journal of the International Society on Toxinology·Michelle Khai Khun YapShin Yee Fung
Mar 19, 1999·Toxicon : Official Journal of the International Society on Toxinology·Z E Selvanayagam, P Gopalakrishnakone
Oct 13, 2009·Toxicon : Official Journal of the International Society on Toxinology·Sueli M MelloStephen Hyslop
Sep 1, 2015·BMC Genomics·Steven D AirdAlexander S Mikheyev
Jan 15, 2014·Toxicon : Official Journal of the International Society on Toxinology·Choo Hock TanNget Hong Tan
Feb 8, 2018·Toxins·Suchaya SanhajariyaGeoffrey K Isbister
Apr 10, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Suchaya SanhajariyaGeoffrey K Isbister

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