PMID: 10095978Mar 30, 1999

Pharmacokinetics of Implanon. An integrated analysis

J Huber, R Wenzl


The aims of this paper were to present data on the pharmacokinetics, clearance, bioavailability, and in vivo absorption of etonogestrel (ENG); to present the results of a longitudinal analysis of the plasma concentration-time curves of ENG; and to present the results of a cross-sectional analysis on the association of body weight with serum ENG concentrations. Implanon had an absorption rate of almost 60 micrograms/day after 3 months, which slowly decreased to 30 micrograms/day at the end of 2 years. The bioavailability over this period of time was constant and close to 100%. The clearance remained around 7.5 L/h. With a bioavailability and clearance that remained constant, it was concluded that accumulation of ENG does not occur. After Implanon insertion, serum concentrations increased within 8 h to concentrations associated with ovulation inhibition. Maximum mean serum concentrations (Cmax) amounted to 813 pg/mL and the time (tmax) to reach Cmax was 4 days. After reaching Cmax, ENG serum concentrations declined to about 196 pg/mL at the end of the first year, followed by a slow decline to 156 pg/mL at the end of the third year. After removal of Implanon, serum ENG concentrations declined to levels less than the detection limi...Continue Reading


Jan 1, 1991·Annals of the New York Academy of Sciences·H B CroxattoI Sivin
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·O PeraltaH B Croxatto
Mar 1, 1995·Clinical Pharmacokinetics·K Fotherby
Dec 1, 1994·Current Opinion in Obstetrics & Gynecology·O A Ladipo, E M Coutinho
Nov 3, 1994·The New England Journal of Medicine·M PolaneczkyS Sondheimer
Sep 1, 1994·Hawaii Medical Journal·Daniel R Mishell
Apr 21, 1998·Fertility and Sterility·L MäkäräinenH J Coelingh Bennink
Mar 30, 1999·Contraception·L Mascarenhas
Mar 30, 1999·Contraception·H B Croxatto, L Mäkäräinen


Feb 28, 2002·Contraception·Alexander Jordan
Feb 28, 2002·Contraception·Laneta J Dorflinger
Feb 28, 2002·Contraception·Horacio B Croxatt
Jul 5, 2011·International Journal of Adolescent Medicine and Health·Amit M DeokarHatim A Omar
Mar 16, 2000·Contraception·S K SuhermanT Korver
Sep 11, 2002·Obstetrics and Gynecology·Thom O M DiebenDan Apter
Dec 1, 2001·Heart Disease·D C O'LoughlinD Singh
Jul 17, 2010·Human Reproduction Update·P D BlumenthalKristina Gemzell-Danielsson
May 7, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Carolina S VieiraRui A Ferriani
Jan 1, 2006·Women's Health·Melissa Simon, Lee P Shulman
Apr 10, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Nils Petter Jørgensen
Jun 22, 2005·Treatments in Endocrinology·Lee P Shulman
Jul 2, 2010·Reproduction, Fertility, and Development·E F HynesMarilyn B Renfree
Jun 9, 2001·Current Opinion in Obstetrics & Gynecology·R Varma, L Mascarenhas
Jul 28, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Costantino Di CarloCarmine Nappi
Oct 10, 2013·Expert Opinion on Drug Metabolism & Toxicology·Giovanni GrandiAnnibale Volpe
May 30, 2008·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Mary A Fischer
Nov 17, 2009·Contraception·Society of Family Planning, Susan Higginbotham
May 3, 2007·Obstetrics and Gynecology Clinics of North America·Stephanie B Teal, David M Ginosar
Aug 2, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A-K VynckierC Vervaet
Jan 18, 2014·The Journal of Pharmacy and Pharmacology·An-Katrien VynckierChris Vervaet
May 11, 2005·Expert Opinion on Investigational Drugs·Megan A Economidis, Daniel R Mishell
Apr 24, 2004·American Journal of Obstetrics and Gynecology·Lee P ShulmanPhilip D Darney
Dec 17, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Katharine B Simmons, Alison B Edelman
Aug 13, 2013·Maturitas·Maureen K Baldwin, Jeffrey T Jensen
May 18, 2010·Contraception·Carolyn L WesthoffFrank Z Stanczyk
Sep 4, 2016·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Judith A SoonEdith Guilbert
Jul 28, 2016·Contraception·Sam RowlandsMartyn Walling
Sep 28, 2016·Human Reproduction·Moazzam AliWHO study group on subdermal contraceptive implants for women
Jul 31, 1999·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·S R ZhengR F Kaper
Jul 27, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J B Otero FloresL Vázquez-Estrada
Apr 24, 2017·Obesity Facts·Joël Schlatter
Sep 12, 2018·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Bárbara C RibeiroIsabel D Reis
May 14, 2017·BMJ Case Reports·Rachel Barlow-EvansMoji Balogun
Nov 9, 2004·The Journal of Family Planning and Reproductive Health Care·Diana Mansour
Aug 8, 2009·International Journal of Dermatology·C Stanley ChanTed Rosen
May 6, 2019·BMJ Sexual & Reproductive Health
Feb 2, 2019·Archives of Gynecology and Obstetrics·Marcia A CicconeKoji Matsuo
Mar 23, 2001·The Annals of Pharmacotherapy·J Le, C Tsourounis
Mar 2, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Salndave B SkosanaJanet P Hapgood

Related Concepts

Process of Absorption
Biological Availability
Contraceptive Agents, Female
Prevalence Studies
Intravenous Infusion Procedures
Longitudinal Survey
Vinyl Compounds

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.