PMID: 2500141Jan 1, 1989Paper

Pharmacokinetics of intra-arterial mitomycin C with or without degradable starch microspheres (DSM) in the treatment of non-resectable liver cancer

Acta Oncologica
M AnderssonH Teder

Abstract

The effects of degradable starch microspheres (DSM) on mitomycin C pharmacokinetics and bone marrow toxicity were studied in a phase II multicenter study. Sixty-three patients with non-resectable primary or secondary liver cancer were randomized to receive either i.a. mitomycin C 15 mg/m2 first, followed 5 weeks later by mitomycin C 15 mg/m2 plus DSM 360 mg administered into the hepatic artery (group I) or the same treatments in the opposite sequence (group II). In 36 out of 47 patients who received at least 2 treatments, peripheral venous blood samples were analyzed for mitomycin C pharmacokinetics on a minimum of 2 paired courses. In all patients, the area under the concentration time curve (AUC) was significantly lower when the drug was co-administrated with DSM, but the terminal half-life (t1/2) of mitomycin C was unchanged. In group I the addition of DSM resulted in a significantly lowered AUC, but not in group II. The discrepancy between the 2 groups is probably due to differences in DSM-induced intra-hepatic shunting. The addition of DSM resulted in significantly higher platelet nadir values, but unchanged white blood cell count nadir value. In conclusion, DSM reduce the systemic exposure of mitomycin C and seem to lesse...Continue Reading

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Citations

Jan 23, 1999·Current Opinion in Oncology·A P Venook
Jan 4, 1998·Journal of Gastroenterology and Hepatology·D Y LinY F Liaw
Nov 28, 1997·The Journal of the Acoustical Society of America·J Agnew
Nov 21, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·G JosephW Klaus
Jan 29, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·K ShitaraY Sakata
May 9, 2003·Surgical Oncology Clinics of North America·Kamran Ahrar, Sanjay Gupta
Dec 11, 2013·Journal of Drug Delivery·Micaela EbertGerd Berger
Jul 11, 2019·The Cochrane Database of Systematic Reviews·Malgorzata M BalaJos Kleijnen
Mar 13, 2020·The Cochrane Database of Systematic Reviews·Mateusz J SwierzMalgorzata M Bala
Feb 6, 2020·The Cochrane Database of Systematic Reviews·Mateusz J SwierzMalgorzata M Bala
Jan 29, 2021·The Cochrane Database of Systematic Reviews·Dawid StormanMalgorzata M Bala

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