Pharmacokinetics of intramuscular artemether in patients with severe falciparum malaria with or without acute renal failure.

British Journal of Clinical Pharmacology
J KarbwangT Harinasuta

Abstract

The pharmacokinetics of intramuscular artemether and its major plasma metabolite-dihydroartemisinin, were investigated in patients with severe manifestations of falciparum malaria. Six severe falciparum malaria patients with acute renal failure (ARF) and 11 without ARF were recruited into the study. They were treated with intramuscular artemether at a loading dose of 160 mg, followed by daily doses of 80 mg for another 6 days (total dose 640 mg). Patients with and without ARF showed a good initial response to treatment; the parasite and fever clearance times were 66(30-164) and 76(36-140) h [median(range)], respectively. None had reappearance of parasitaemia in their peripheral blood smear within 7 days of initiation of treatment. In comatose patients, the time to recovery of consciousness was 51.6(22-144) h. Artemether was detected in plasma as early as 1 h after a 160 mg dose, and declined to undetectable levels within 24 h in most cases. Patients with ARF had significantly higher Cmax [2.38(1.89-3.95) vs 1.56(1.05-3.38) ng ml(-1) mg(-1) dose], AUC [35.4(22-52.9) vs 25.2(13.4-52.9) ng ml(-1) h mg(-1) dose], and lower Vz/F [5.45(3.2-6.9) vs 8.6(4.2-12.3) l kg(-1)] and CL/F [7.4(5.4-13.8) vs 19.1(8.5-25.1) ml min(-1) kg(-1)] wh...Continue Reading

References

Jan 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene· Pe Than Myint Win Myint
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene· Pe Than Myint, Tin Shwe
Mar 1, 1994·Acta Tropica·W H Wernsdorfer
Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·J KarbwangT Harinasuta
Jul 11, 1996·The New England Journal of Medicine·M B van HensbroekD Kwiatkowski
Jul 11, 1996·The New England Journal of Medicine·T H TranN J White
Jul 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·D BunnagT Harinasuta
Jan 1, 1997·European Journal of Clinical Pharmacology·J KarbwangA Thanavibul

❮ Previous
Next ❯

Citations

Jun 26, 2001·European Journal of Drug Metabolism and Pharmacokinetics·K Na-BangchangS Saenglertsilapachai
Jul 25, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Qigui LiPeter J Weina
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Kamolrat SilamutNicholas J White
Feb 24, 2006·Antimicrobial Agents and Chemotherapy·Harin A KarunajeewaTimothy M E Davis
Feb 11, 2005·Postgraduate Medical Journal·C J WoodrowS Krishna
Jan 15, 2010·Malaria Journal·Bruno B AndradeManoel Barral-Netto
Nov 9, 2000·Clinical Pharmacokinetics·V NavaratnamP Olliaro
Nov 9, 2015·European Journal of Drug Metabolism and Pharmacokinetics·Iftekhar MahmoodRita Humeniuk
Aug 6, 2014·Antimicrobial Agents and Chemotherapy·S M D K Ganga Senarathna, Kevin T Batty
Jun 1, 2005·Biopharmaceutics & Drug Disposition·S SabarinathR C Gupta
Jan 27, 2018·Biomédica : revista del Instituto Nacional de Salud·Sebastián Barrera, Alberto Tobón-Castaño
Oct 20, 2005·Clinical Pharmacokinetics·Sreedharan N SabarinathRam C Gupta
Mar 1, 2017·BMC Complementary and Alternative Medicine·Susy Tjahjani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.