Pharmacokinetics of intraperitoneal and intravenous fosfomycin in automated peritoneal dialysis patients without peritonitis.

Antimicrobial Agents and Chemotherapy
Selma TobudicHeinz Burgmann

Abstract

Blood and dialysate concentrations of fosfomycin were determined after intravenous and intraperitoneal application of 4 mg/liter in patients undergoing automated peritoneal dialysis. Maximum serum concentrations after intravenous (287.75 ± 86.34 mg/liter) and intraperitoneal (205.78 ± 66.78 mg/liter) administration were comparable. Ratios of intraperitoneal to systemic exposure were 1.12 (intraperitoneal administration) and 0.22 (intravenous administration), indicating good systemic exposure after intraperitoneal application but limited penetration of fosfomycin into the peritoneal fluid after the intravenous dose.

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Citations

Aug 12, 2015·PloS One·Eugene KwonUNKNOWN Clinical Research Center for End Stage Renal Disease (CRC for ESRD) Investigators
Feb 18, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Edwin LamJingjing Zhang
Jul 15, 2017·The International Journal of Artificial Organs·Abdullah K Al-HwieshNourah Al-Dossari
Jul 8, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M KussmannG Reznicek
Mar 17, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Manuel KussmannMartin Wiesholzer
Feb 10, 2021·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Chau Wei LingRonald L Castelino
Mar 11, 2016·Clinical Microbiology Reviews·Matthew E FalagasKonstantinos Z Vardakas

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