Pharmacokinetics of intravenous immunoglobulin in multifocal motor neuropathy

Journal of Neurology, Neurosurgery, and Psychiatry
Lotte VlamW-Ludo van der Pol

Abstract

Multifocal motor neuropathy (MMN) is often responsive to treatment with intravenous immunoglobulin (IVIg), but the optimal dose and intervals of IVIg maintenance treatment have not been established. Increase in IgG concentration (ΔIgG) after IVIg infusion has recently been identified as determinant of outcome in Guillain-Barré syndrome. ΔIgG may therefore represent a potentially useful biomarker to optimise IVIg dosing in patients with MMN. The aims of this study were to determine variability of IVIg pharmacokinetics in patients with MMN in relation to treatment response, and to establish whether interindividual differences in IVIg pharmacokinetics were associated with genetic polymorphisms of the endothelial IgG receptor (FcRn) which determines IgG half-life. Twenty-three patients with MMN receiving their first IVIg treatment at a cumulative dose of 2.0 g/kg in 5 days were included. A good treatment response was defined as an increase in muscle strength of at least one Medical Research Council point in minimally two muscle groups. IgG concentrations in serum were determined at baseline, at day 1 and day 5 of the IVIg course, and 3 weeks after treatment. FcRn copy number variation and differences in repeat length of the variabl...Continue Reading

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Citations

Apr 15, 2014·Journal of Clinical Immunology·Oliver HarschnitzLeonard H van den Berg
Dec 3, 2014·Revue neurologique·T Kuntzer
Sep 25, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jan D LünemannMarinos C Dalakas
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Aug 26, 2014·Journal of Neurology·Dario CocitoUNKNOWN SCIg and Chronic Dysimmune Neuropathies Italian Network
Mar 4, 2015·Clinical and Experimental Immunology·J P HodkinsonH Chapel
Jul 15, 2015·Neurology. Neuroimmunology and Neuroinflammation·Lotte VlamW Ludo van der Pol
Jan 8, 2015·Frontiers in Immunology·Jacqueline KerrHans-Hartmut Peter
Jul 8, 2016·Annals of Clinical and Translational Neurology·Willem-Jan R FokkinkBart C Jacobs
Oct 23, 2016·Experimental Neurology·Luise AppeltshauserKathrin Doppler
Feb 23, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A TotzeckT Hagenacker
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Aug 28, 2020·The International Journal of Neuroscience·Mahima Kapoor Carr
May 8, 2021·International Immunopharmacology·Jian Lynn LeeShamin Mohd Saffian

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