PMID: 3766095Jul 1, 1986Paper

Pharmacokinetics of intravenous, intrathecal and epidural morphine and fentanyl in the goat

Acta Anaesthesiologica Scandinavica
H B AndersenJ A Jansen

Abstract

Intrathecal and epidural catheters and an intravenous cannula were inserted in 10 goats. After administration of either morphine 4 mg, intravenously, 1 mg intrathecally or 4 and 8 mg epidurally, or fentanyl 0.1 mg intravenously, 0.05 mg intrathecally or 0.1 and 0.2 mg epidurally, venous blood and CSF were sampled at 2, 5, 10, 15, 30 min and 1, 2, 4, 6, 8 and 24 h. The concentrations of the drugs were measured by radioimmunoassay. After administration of intravenous morphine the plasma concentration-time curve fitted a 3-compartment model (body clearance = 84 +/- 23 ml/min/kg, mean +/- s.d., N = 5), while after fentanyl the plasma concentration-time curve was best described by a 2-compartment model (body clearance = 3.9-5.8 ml/min/kg, N = 3]. After intrathecal injection the elimination rates of the opioids from CSF were 0.3 to 2.0 and 0.6 to 2.4 ml/h/kg for morphine and fentanyl, respectively (N = 3). The time to reach maximum CSF concentration after epidural administration was 0.22 +/- 0.14 h for morphine (N = 6) and 0.22 +/- 0.13 h for fentanyl (N = 8). In the same goat the CSF availability was 2.3 and 11.3% for morphine and 0.8 and 3.3% for fentanyl following epidural administration of the low and high doses, respectively. Af...Continue Reading

References

Oct 14, 1977·European Journal of Clinical Pharmacology·M MichielsJ Heykants
Mar 1, 1982·British Journal of Anaesthesia·T A Torda, D A Pybus
Oct 1, 1984·Acta Anaesthesiologica Scandinavica·L L GustafssonB Schildt
Jan 1, 1984·Clinical Pharmacology and Therapeutics·A MooreA Cole
Jan 1, 1984·Acta Anaesthesiologica Scandinavica. Supplementum·G Nordberg
Jun 1, 1983·Anesthesiology·G NordbergB Dahlström
Dec 1, 1981·Anesthesiology·B C JørgensenA Engquist
Sep 1, 1980·British Journal of Anaesthesia·J H ChristensenJ A Jansen
Nov 1, 1962·The American Journal of Physiology·S R HEISEYJ R PAPPENHEIMER

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Citations

May 28, 2005·International Journal of Pharmaceutics·Frederic LagarceJean-Pierre Benoit
Aug 26, 2003·Advanced Drug Delivery Reviews·Carolyn A Fairbanks
Aug 1, 1993·Acta Anaesthesiologica Scandinavica·M I ZakowskiH Turndorf
Jun 1, 1990·Journal of Pain and Symptom Management·M B Sabbe, T L Yaksh
Dec 1, 1993·Archives of Disease in Childhood·R Howard

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