Pharmacokinetics of intravenously and subcutaneously administered Fragmin in healthy volunteers

Haemostasis
D LocknerW Aberg

Abstract

Studies in 8 healthy volunteers showed that the low molecular weight heparin Fragmin KabiVitrum is eliminated according to first order kinetics without dose dependency after intravenous injection of doses between 40 and 120 anti-Xa U/kg. Fragmin remains in the circulation more than twice as long as unfractionated heparin (UFH). Fragmin administered subcutaneously has a bioavailability which is much greater than that of UFH. Fragmin administered subcutaneously twice a day results in a significant anti-Xa activity and provides an alternative to intravenous infusions.

Citations

Oct 17, 1992·BMJ : British Medical Journal·A LeizoroviczJ P Boissel
Apr 9, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M WiesholzerP Balcke
Feb 1, 1988·American Journal of Hematology·H ten CateH R Büller
Jan 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J SwedenborgN Egberg

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